Publications by authors named "T Nissen"
The role of myeloid cells in the pathogenesis of SARS-CoV-2 is well established, in particular as drivers of cytokine production and systemic inflammation characteristic of severe COVID-19. However, the potential for myeloid cells to act as bona fide targets of productive SARS-CoV-2 infection, and the specifics of entry, remain unclear. Using a panel of anti-SARS-CoV-2 monoclonal antibodies (mAbs) we performed a detailed assessment of antibody-mediated infection of monocytes/macrophages.
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- A study examined the relationship between Doppler ultrasound-derived mean fenestration gradient (mFG) and direct measurements of transpulmonary gradient (TPG) in patients who underwent the Fontan procedure, a common surgical treatment for single ventricle anatomy.
- The research included 59 patients from a single center between 2000 and 2022 and found that mFG and TPG were weakly correlated, indicating that mFG can only explain about 38% of the variance in TPG measurements.
- The study suggests that while mFG offers a non-invasive way to assess TPG, healthcare providers should be cautious and consider direct catheterization for accurate evaluations in Fontan patients.
Sudden Cardiac Arrest in 12-Year-Old BoyA 12-year-old boy suddenly lost consciousness while playing catch in his backyard. He was found pulseless and received cardiopulmonary resuscitation and defibrillation before being transferred to the emergency department. How do you approach the evaluation, and what is the diagnosis?
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