Clinicopathological and prognostic significance of stromal p16 and p53 expression in oral squamous cell carcinoma.

The tumor microenvironment is highly heterogeneous and consists of neoplastic cells and diverse stromal components, including fibroblasts, endothelial cells, pericytes, immune cells, local and bone marrow-derived stromal stem and progenitor cells, and the surrounding extracellular matrix. Although the significance of p16 and p53 has been reported in various tumor types, their involvement in the stromal cells of oral squamous cell carcinoma (OSCC) remains unclear. We performed immunohistochemical analyses of p16 and p53 expression in OSCC samples, Of the 116 samples, 74 showed p16-positive stromal cells, and 33 showed p53-positive stromal cells.

Two Cases of Refractory Diarrhea Subsequent to Vascular Reconstruction for Infective Superior Mesenteric Artery Aneurysms.

Superior mesenteric artery (SMA) aneurysm and their surgical interventions are rare, leading to infrequent reports of postoperative complications. This report describes 2 cases of refractory diarrhea following vascular reconstruction for infectious SMA aneurysms. Both patients underwent aneurysm resection and SMA reconstruction but experienced persistent diarrhea despite treatment with anti-diarrheal medications.

[Extensive Spinal Cord Infarction Subsequent to Total Arch Replacement for Stanford Type A Acute Aortic Dissection:Report of a Case].

A 53-year-old male, diagnosed with Stanford A acute aortic dissection, underwent a total arch replacement with a conventional elephant trunk. During the extubation phase, paraplegia and sensory disturbance were identified, prompting suspicion of spinal cord injury (SCI) attributed to thrombosis of the false lumen and subsequent obstruction of the segmental arteries. Apixaban was administered in addition to spinal drainage, meticulous blood pressure management, and administration of mannitol, edaravone, naloxone, and prednisolone.

A non-toxic equinatoxin-II reveals the dynamics and distribution of sphingomyelin in the cytosolic leaflet of the plasma membrane.

Sphingomyelin (SM) is a major sphingolipid in mammalian cells. SM is enriched in the extracellular leaflet of the plasma membrane (PM). Besides this localization, recent electron microscopic and biochemical studies suggest the presence of SM in the cytosolic leaflet of the PM.