Publications by authors named "T Niinuma"
Recent studies have shown that long noncoding RNAs (lncRNAs) play pivotal roles in the development and progression of cancer. In the present study, we aimed to identify lncRNAs associated with lymph node metastasis in pancreatic ductal adenocarcinoma (PDAC). We analyzed data from The Cancer Genome Atlas (TCGA) database to screen for genes overexpressed in primary PDAC tumors with lymph node metastasis.
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- Long noncoding RNAs (lncRNAs) are important in cancer development, but their roles in oral squamous cell carcinoma (OSCC) are not fully understood; LINC02154 has been found to be linked to worse outcomes in patients.
- Knocking down LINC02154 in OSCC cells leads to cell cycle arrest and death, and reduces tumor growth by downregulating the gene FOXM1, which regulates cell cycle progression.
- LINC02154 also interacts with proteins that stabilize FOXM1 and affects mitochondrial function, suggesting it could be a potential target for cancer therapies by influencing both cell cycling and energy production in OSCC cells.
The tumor microenvironment plays a pivotal role in cancer development. We recently reported that in oral squamous cell carcinoma (OSCC), adipocyte enhancer-binding protein 1 (AEBP1) is abundantly expressed in cancer-associated fibroblasts (CAFs), leading to CAF activation and inhibition of CD8 + T cell infiltration. In the present study, we investigated whether AEBP1 contributes to the destruction and atrophy of muscle tissues in OSCC.
View Article and Find Full Text PDFBackground: Aberrant DNA methylation is prevalent in colorectal serrated lesions. We previously reported that the CpG island of SMOC1 is frequently methylated in traditional serrated adenomas (TSAs) and colorectal cancers (CRCs) but is rarely methylated in sessile serrated lesions (SSLs). In the present study, we aimed to further characterize the expression of SMOC1 in early colorectal lesions.
View Article and Find Full Text PDFWe previously showed that upregulation of adipocyte enhancer-binding protein 1 () in vascular endothelial cells promotes tumor angiogenesis. In the present study, we aimed to clarify the role of stromal /ACLP expression in oral squamous cell carcinoma (OSCC). Immunohistochemical analysis showed that ACLP is abundantly expressed in cancer-associated fibroblasts (CAFs) in primary OSCC tissues and that upregulated expression of ACLP is associated with disease progression.
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