Publications by authors named "T Niikura"
Article Synopsis
- - Low-intensity pulsed ultrasound (LIPUS) and transcutaneous carbon monoxide (CO) therapy were tested in rats to determine if their combined use would enhance fracture healing more effectively than using either treatment alone.
- - The study created femoral shaft fractures in rats and divided them into four groups: combination (LIPUS + CO), LIPUS only, CO only, and a control group, treating them regularly for four weeks and assessing bone healing through various methods.
- - Results showed that the combination group had significantly better fracture healing scores, higher vascular density, and increased gene expression related to bone growth compared to the control and single therapy groups at multiple time points throughout the study.
Article Synopsis
- Transcutaneous CO application was shown to enhance muscle fiber-type switching, fracture healing, and bone growth by increasing blood flow and new blood vessel formation.
- In a rat study, transcutaneous CO treatment prevented muscle atrophy and bone loss that typically occur with inactivity, as seen in the hindlimb suspension model.
- Results indicated that rats treated with CO had larger muscle fibers, healthier bone structure, and better expression of markers related to muscle and bone growth compared to those not receiving the treatment.
SUMO1 modification of 0N4R-tau is regulated by PIASx, SENP1, SENP2, and TRIM11.
Biochem Biophys Rep
September 2024
Tau is a microtubule-associated protein that contributes to cytoskeletal stabilization. Aggregation of tau proteins is associated with neurodegenerative disorders such as Alzheimer's disease. Several types of posttranslational modifications that alter the physical properties of tau proteins have been identified.
View Article and Find Full Text PDFBACKGROUND Infection control and reconstruction of bone and soft tissue are essential for treating infected nonunion. Continuous local antibiotic perfusion (CLAP) is a drug delivery system that continuously delivers antibiotics at the required concentration, area, and duration. This case report describes the instance of infected nonunion in which infection eradication and bone union were achieved using CLAP and synthetic bone grafting while retaining the implant.
View Article and Find Full Text PDFThe interconnected structures in a 3D scaffold allows the movement of cells and nutrients. Therefore, this study aimed to investigate the in-vivo bioactivity of 3D-printed β-tricalcium phosphate (β-TCP) and hydroxyapatite (HAP) scaffolds that replicate biological bone. This study included 24-week-old male New Zealand white rabbits.
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