Publications by authors named "T Niemi"
Background: Breast cancer-related lymphedema (BCRL) is a common complication lacking medical treatment. Lymfactin® is an adenovirus type 5-based gene therapy and prolymphangiogenic growth factor vector that induces vascular endothelial growth factor C (VEGF-C) expression. Our aim was to evaluate the therapeutic effect of Lymfactin® with vascularized lymph node transfer (VLNT).
View Article and Find Full Text PDFCold-induced brown adipose tissue (BAT) activation is considered to improve metabolic health. In murine BAT, cold increases the fundamental molecule for mitochondrial function, nicotinamide adenine dinucleotide (NAD), but limited knowledge of NAD metabolism during cold in human BAT metabolism exists. We show that cold increases the serum metabolites of the NAD salvage pathway (nicotinamide and 1-methylnicotinamide) in humans.
View Article and Find Full Text PDFBackground: Sepsis is a leading cause of morbidity and mortality. Prompt recognition and management are critical to improve outcomes.
Methods: We conducted a survey among nurses and physicians of all adult departments of the Lausanne University Hospital (LUH) and paramedics transporting patients to our hospital.
Article Synopsis
- The study looks at how the outer structure of fat tissue, called the extracellular matrix (ECM), changes in brown fat (BAT) and how it affects body temperature regulation and obesity.
- Researchers found that when mice eat a high-fat diet, it causes problems in the brown fat, leading to inflammation and less fat-burning ability.
- The findings suggest that understanding these changes in ECM can help explain why brown fat doesn't work properly in people with obesity.
Background: Research focusing on predictors for discharge destination after rehabilitation of inpatients recovering from severe stroke is scarce. The predictive value of rehabilitation admission NIHSS score among other potential predictors available on admission to rehabilitation has not been studied.
Aim: The aim of this retrospective interventional study was to determine the predictive accuracy of 24 hours and rehabilitation admission NIHSS scores among other potential socio-demographic, clinical and functional predictors for discharge destination routinely collected on admission to rehabilitation.