Publications by authors named "T Nell"
Relatively little work has focused on why we are motivated to learn words. In adults, recent experiments have shown that intrinsic reward signals accompany successful word learning from context. In addition, the experience of reward facilitated long-term memory for words.
View Article and Find Full Text PDFArticle Synopsis
- Obesity is a complex disease linked to metabolic syndrome and co-morbidities, which leads to low-grade chronic inflammation due to the dysregulation of adipose tissue expansion and changes in inflammatory mediators.
- The study focused on the anti-inflammatory protein annexin A1, showing that its levels increased after bariatric surgery and were lower in lipodystrophy patients, suggesting a correlation with inflammation and obesity-related conditions.
- An in vitro experiment with SGBS cells indicated that treatment with an annexin A1 peptide positively affected the expression of key genes involved in fat metabolism and inflammation, providing insights into its potential therapeutic role in obesity.
Article Synopsis
- Intra-regional cultural and linguistic differences challenge health education in low- and middle-income countries, necessitating innovative teaching methods like the Community Orientation Program (COP) to sensitize medical students to social determinants of health.
- The COP, developed using the ADDIE model, focuses on enhancing students' communication skills and observational abilities through hands-on community engagement and collaborative learning in an Indian setting.
- Feedback from over 550 students trained through the COP indicates it improved their understanding of socio-demographic factors in health, respect for local culture, and communication skills, although suggestions for enhancing clinical examination practices were noted.
Adipocytes in the breast tumour microenvironment promotes acquired treatment resistance. We used an in vitro adipocyte-conditioned media approach to investigate the direct paracrine effects of adipocyte secretory factors on MDA-MB-231 breast cancer cells treated with doxorubicin to clarify the underlying treatment resistance mechanisms. Cell-viability assays, and Western blots were performed to determine alterations in apoptotic, proliferation and lipid metabolism protein markers.
View Article and Find Full Text PDFPacemaker endocarditis is rare and symptoms may be misleading. If missed, it carries significant morbidity and mortality, particularly in the elderly. Advances in multi-modality imaging in recent years have emphasised its role in clinical decision making.
View Article and Find Full Text PDF