THE RELATIONSHIP BETWEEN THE DURATION OF REMISSIONS AFTER THE ONSET, THE SEVERITY OF THE RELAPSES AGAINST THE BACKGROUND OF DIFFERENT DURATION OF THE RELAPSING STAGE AND THE NATURE OF THE PROGNOSIS IN SECONDARY-PROGRESSIVE MULTIPLE SCLEROSIS.

Work objective - to study the relationship between the duration of remission after the onset, the severity of relapses against the background of different duration of the relapsing stage (RS) and the nature of the prognosis in the secondary progressive multiple sclerosis (SPMS) using clinical and mathematical analysis. Patients with different prognosis for SPMS; neurological examination using The Expanded Disability Status Scale (EDSS); a survey method. Mathematical methods: 'contingency tables 2x2' (determining the significance of the connection between a pair of two indicators - different duration of remission after the onset and RS in four groups of patients), Yule's Coefficient of Association (determining the magnitude of differences between the group and the studied indicator), a permutation test (defining clinical indicators on RS, which significantly differed in mild and severe relapses).

[NEUROPSYCHOLOGICAL ANALYSIS OF DISORDERS OF HIGHER MENTAL FUNCTIONS IN PATIENTS WITH DIFFERENT TYPES OF MULTIPLE SCLEROSIS].

Patients with RR (n=45) and SP (n=24) types of multiple sclerosis (MS) were analyzed using original Luria neuropsychological battery. On the basis of the results obtained, the general characteristics of neuropsychological syndromes were determined: asthenic manifestations; certain violations of the auditory-speech memory; decreased visual memory; disorders of interhemispheric somatosensory transfer; violations of the simultaneous factor of the mental activity organization. It is shown that the progressive type of MS is characterized by a significantly greater degree of severity of the above disorders, as well as their certain qualitative features: a wider range of mnestic disorders; the presence of disturbances in the interhemispheric transfer of motor information; the presence of violations of the assessment of rhythmic sequences by ear; the presence of visual-constructive activity disorders.

[CLINICAL-MATHEMATICAL ANALYSIS OF INTERRELATIONS BETWEEN A CHARACTER OF THE PROGNOSIS AND PECULIARITIES OF ONSETS IN DIFFERENT TYPES OF MULTIPLE SCLEROSIS COURSE].

Aim of the study- to assess the prognostic value of indicators characterizing the course of the of multiple sclerosis onset (MS) using clinical-mathematical analysis. Patients with MS with different prognosis: good and uncertain for the relapsing-remitting type; uncertain and poor for progressive types of clinical course. A neurological examination using The Expanded Disability Status Scale (EDSS); a questionnaire method; determination of the Yule's coefficient of association (coefficient of colligation), the separating hyperplane method and the correlation analysis.