Publications by authors named "T Nadasdy"
Article Synopsis
- Proteins are filtered from blood by the glomerular filtration barrier and then reabsorbed by proximal tubular epithelial cells (PTECs), which create tubular protein reabsorption droplets (TPRDs) from these proteins.
- A study analyzing 109 kidney biopsies found a negative correlation between albumin TPRDs and proteinuria, while positive correlations were observed between proteinuria and IgG TPRDs and acute tubular necrosis (ATN).
- The findings suggest that healthy PTECs are crucial for managing protein levels in urine, as their effectiveness declines with conditions like ATN, leading to increased proteinuria.
Background: Although is the leading cause of acute infective endocarditis (IE) in adults, spp. has concomitantly emerged as the leading cause of "blood culture-negative IE" (BCNE). Pre-disposing factors, clinical presentation and kidney biopsy findings in Bartonella IE-associated glomerulonephritis (GN) show subtle differences and some unique features relative to other bacterial infection-related GNs.
View Article and Find Full Text PDFAmyloidosis is an infiltrative disease caused by misfolded proteins depositing in tissues. Amyloid infiltrates the kidney in several patterns. There are, as currently described by the International Society of Amyloidosis, 14 types of amyloid that can involve the kidney, and these types may have different locations or clinical settings.
View Article and Find Full Text PDFContext: Infection-related glomerulonephritis (IRGN) usually manifests as a proliferative immune-complex glomerulonephritis. The degree of renal dysfunction at presentation can vary. Association with histologic features on kidney biopsy remains unknown.
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