Natural antimicrobial peptide complexes in the fighting of antibiotic resistant biofilms: Calliphora vicina medicinal maggots.

Biofilms, sedimented microbial communities embedded in a biopolymer matrix cause vast majority of human bacterial infections and many severe complications such as chronic inflammatory diseases and cancer. Biofilms' resistance to the host immunity and antibiotics makes this kind of infection particularly intractable. Antimicrobial peptides (AMPs) are a ubiquitous facet of innate immunity in animals.

Insect Antimicrobial Peptide Complexes Prevent Resistance Development in Bacteria.

In recent decades much attention has been paid to antimicrobial peptides (AMPs) as natural antibiotics, which are presumably protected from resistance development in bacteria. However, experimental evolution studies have revealed prompt resistance increase in bacteria to any individual AMP tested. Here we demonstrate that naturally occurring compounds containing insect AMP complexes have clear advantage over individual peptide and small molecule antibiotics in respect of drug resistance development.

[Healthcare-associated infections. The current state of the problem].

The current article elucidates some novel trends in the field of healthcare-associated infections emerged in the foreign scientific medical publications over the last year and a half (January 2013 - June 2014). The following topics are covered: definition of the term, the body of publications bibliometrics, classification, statistics, patient-to-professional infection transmission, control and prevention, specialized national organizations, new guidelines and a new monograph on the theme. The conducted analysis demonstrates the significance of the topic and the high rate of research in the field.

[Medical-and-economic substantiation of rational antibacterial therapy for patients with pleural empyema in the conditions of military medical institutions].

We have performed a post-hoc analysis of the results of using antibacterial therapy in patients with pleural empyema. The cost-effectiveness analysis of rational and empiric antibacterial therapies was performed. The cost-effectiveness ratio for rational antibacterial therapy was lower than for empiric one (2889 and 4480 rubles for 1 treated patient correspondingly).

[Primary causative agents of infectious complications in injured with severe trauma].

Aim: Study etiologic structure of infectious complications in injured with severe-trauma.

Materials And Methods: Retrospective analysis of results of therapy outcomes in 5966 wounded and injured (1999 - 2009) and prospective observation of 142 injured (2008 - 2009) by using epidemiologic, statistical and microbiological methods was carried out.

Results: Frequency of isolation and specific weight of causative agents depending on localization of infectious complication was established.