Silver nanoparticle-based SERS sensors for sensitive detection of amyloid-β aggregates in biological fluids.

One of the hallmarks of Alzheimer's disease (AD) pathogenesis is the production, aggregation, and deposition of amyloid-β (Aβ) peptide. Surface-enhanced Raman spectroscopy (SERS) is a promising analytical technique capable of providing valuable information on chemical composition and molecule conformations in biological samples. However, one of the main challenges for introducing the SERS technique into the practice is preparation of scalable and at the same time stable nanostructured sensors with uniform spatial distribution of nanoparticles.

Plier Ligands for Trapping Neurotransmitters into Complexes for Sensitive Analysis by SERS Spectroscopy.

Catecholamines-dopamine, noradrenaline and adrenaline are important biomarkers of neurotransmitter metabolism, indicating neuroendocrine tumors and neurodegenerative diseases. Surface-enhanced Raman spectroscopy (SERS) is a promising analytical technique with unprecedented multiplexing capabilities. However, not all important analytes exhibit strong SERS signals on stable and robust nanostructured substrates.

Molecular Immobilization and Resonant Raman Amplification by Complex-Loaded Enhancers (MIRRACLE) on copper (II)-chitosan-modified SERS-active metallic nanostructured substrates for multiplex determination of dopamine, norepinephrine, and epinephrine.

A unique approach based on Molecular Immobilization and Resonant Raman Amplification by Complex-Loaded Enhancers (MIRRACLE) on copper (II)-chitosan-modified SERS-active metallic nanostructured substrates is proposed for sensitive and rapid determination of the catecholamines (CA) dopamine, norepinephrine, and epinephrine. The ternary (CA)Cu(4AAP) complexes were characterized by the appearance of new absorbance bands at 555, 600, and 500 nm for dopamine, norepinephrine, and epinephrine, respectively. The new absorbance band matched with a broad surface plasmon resonance band of utilized silver nanoparticles: 450-600 nm, and 633 excitation wavelength.

VACCINATION IN THE SYSTEM OF HUMAN RIGHTS AND OBLIGATIONS: IMPACT OF THE COVID-19 PANDEMIC.

Objective: The aim: To identify the problems and prospects of introducing mandatory vaccination against COVID-19 in the context of respect for human and civil rights and freedoms based on generalization and systematization of foreign experience in implementing such measures.

Patients And Methods: Materials and methods: In the research, we applied a complex of philosophical and ideological approaches, general scientific and special methods of scientific cognition, in particular civilizational and axiological approaches as well as dialectical, dogmatic, comparative, and statistical methods. The empirical basis of the study is represented by the statistical data of the healthcare sector of European countries, generalization of the practice of vaccination.

Dual-Purpose SERS Sensor for Selective Determination of Polycyclic Aromatic Compounds Electron Donor-Acceptor Traps.

Toxic, carcinogenic, and mutagenic properties of polycyclic aromatic hydrocarbons (PAHs) and environmental pollution caused by polycyclic aromatic sulfur heterocycles (PASHs) postulate the importance of their selective and sensitive determination in environmental and oil fuel samples. Surface-enhanced Raman spectroscopy (SERS) opens up an avenue toward multiplex analysis of complex mixtures, however not every molecule gives high enhancement factors and, thus, cannot be reliably detected SERS. However, the sensitivity can be drastically increased by additional resonant enhancement as a result of the analyte absorption band overlapping with the surface plasmon band of nanoparticles (NPs) and the laser excitation wavelength.