Publications by authors named "T N Seth"
A boy in middle childhood presented with complaints of swelling and pain in his right forearm for 4 months. He had previously undergone left above-elbow amputation due to a suspected malignant tumour in that arm. Radiological imaging revealed a locally aggressive bone tumour of the right distal radius.
View Article and Find Full Text PDFBackground & objectives Timely detection of population with β-thalassemia trait (BTT) followed by genetic counselling is an advocated method of preventing the birth of a child with β-thalassemia major. In this study we aim to assess the diagnostic accuracy of Gazelle, a point-of-care (POC) testing device, in screening for BTT in hospital laboratory setting. Methods Standards for Reporting Diagnostic Accuracy (STARD) guidelines were followed in developing study design, recruiting study participants and sample size calculation for the current research.
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- Mesenchymal stem cells (MSCs) have shown promise for treating diseases with immune disorders, such as Graft-versus-Host-Disease (GVHD), and their effectiveness depends on how they behave after administration.
- The study involved deriving human MSCs from bone marrow and Wharton's Jelly, preconditioning them in low-oxygen environments, and assessing their impact on immune responses, particularly looking at T cell behavior and macrophage polarization.
- Results indicated that MSCs preconditioned through hypoxia and apoptosis (especially those from Wharton's Jelly) had superior immune-modulating abilities, improving Treg differentiation and shifting macrophages toward a more anti-inflammatory state, suggesting a novel approach for treating aGVHD.
Sickle cell disease (SCD) with vaso-occlusive pain crisis (VOC) significantly impacts patient well-being and often results in extensive healthcare resource utilization. This study assessed the VOC burden, its management and its impact on patients' quality of life (QoL). A cross-sectional observational study was conducted between November 2021 and June 2022, including 1000 SCD patients from high-prevalence states in India.
View Article and Find Full Text PDFAim This study aims to comparatively evaluate the stress distribution and deformation in class II cavities restored with EverX posterior and Activa Bioactive restorative material using three-dimensional finite element analysis. Methods On a mandibular first molar tooth model, features of a class II mesio-occlusal cavity were designed. Following the application of EverX Posterior and Activa Bioactive, the model was subjected to a 600 N static occlusal load.
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