Publications by authors named "T N Mills"
In acute myeloid leukemia (AML), leukemogenesis depends on cell-intrinsic genetic aberrations and thus, studies on AML require investigations in an in vivo setting as provided by patient derived xenografts (PDX) models. Here we report that, next to leukemic cell characteristics, recipient sex highly influences the outgrowth of AML cells in PDX models, with females being much better repopulated than males in primary as well as secondary transplantation assays. Testosterone may be the more important player since, strikingly, better engraftment was seen in castrated versus control male recipients, while ovariectomy did not significantly impair engraftment in females.
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- - Communities of Practice (CoPs) show promise in enhancing community-centered health promotion, specifically in addressing gambling harms among voluntary, community, faith, and social enterprises (VCFSE) in a city-region in England.
- - The evaluation included 33 qualitative interviews and focused on building a mid-level program theory, revealing that the CoP helped foster community interventions through staff understanding and collaboration, despite inconsistencies in project-level outcomes.
- - Ultimately, CoPs proved effective alongside VCFSE projects and individuals with lived experience, contributing to a knowledge base that supports the government's strategy for reducing gambling-related issues.
Context: The risk of early neurodevelopmental delay is increasingly recognized in children born moderate-to-late preterm (MLP; 32-36 weeks' gestation), but school-aged cognitive outcomes are unclear, particularly for domains such as executive function (EF).
Objective: To evaluate EF outcomes (attentional control, cognitive flexibility, and goal setting) in school-aged children born MLP compared with children born at term.
Data Sources: Medline, Embase, PsycInfo, and Scopus.
Article Synopsis
- Fungal endophytes significantly enhance the health and productivity of both native and cultivated plants, but research on their communities in eucalypt species remains limited.
- This study focused on the seasonal and spatial dynamics of fungal leaf endophytes in Eucalyptus crebra, finding that summer had significantly higher fungal diversity compared to autumn and spring.
- The results revealed different fungal compositions across seasons and canopy levels, with Ascomycota being the most prevalent phylum year-round, and highlighted the importance of monitoring endophytic fungi for the health of E. crebra and similar species.
Article Synopsis
- The study explores the oral healthcare challenges faced by people with scleroderma, highlighting that these issues are poorly understood despite being frequently reported by patients.
- Surveys and interviews with patients, dentists, and rheumatologists in the UK revealed that a high percentage of patients (95.5%) experience oral and dental manifestations, significantly affecting their quality of life in physical, psychological, and social domains.
- Key findings suggest that most healthcare providers lack confidence in managing these challenges, and there’s a need for better communication and information sharing between medical and dental practitioners to improve patient care.