A method for simulating cardiac hypopolarization arrhythmias was developed in order to study changes in cardiomyocyte membrane hypopolarization under the effects of antiarrhythmics and other drugs. The method is based on registration of K(+)-induced arrhythmias after intravenous injection of a minimum arrhythmogenic dose of 1.5% KCl over 2 sec.
View Article and Find Full Text PDFPathogenesis of cardiac arrhythmia was determined by EEC changes after ATP-induced complete atrioventricular block. The re-entry mechanism underlays extrasystoles with equal coupling intervals with complexes of ventricular substitution rhythms, which transformed into paroxysmal tachycardia with equal R-R intervals, ventricular flutter, and ventricular fibrillation. Ectopic automaticity was characterized by extrasystole unrelated to the complexes of substitutional rhythms, which was transformed into accelerated idioventricular rhythm and asystole.
View Article and Find Full Text PDFBull Exp Biol Med
April 2006
The arrhythmic effects of Na+ and Ca2+ intracellular imbalance were examined on rats with aconitine-induced cardiac arrhythmias. Under conditions of Na(+)-dependent arrhythmogenesis, blockade of Ca(2+)-channels with verapamil aggravated cardiac rhythm disturbances. Correction of ionic imbalance by intravenous injection of calcium preparations in aconitine-induced arrhythmia promoted recovery of stable sinus rhythm and decreased animal mortality.
View Article and Find Full Text PDFWe propose a method for experimental modeling of cardiac arrhythmias. The method consists in intravenous injection of LPO inductors: 5% ascorbic acid (50 mg/kg), 1 min later 1% iron sulfate (10 mg/kg), and after the appearance of giant T waves on ECG infusion of 10% calcium chloride in a nonarrhythmogenic dose 100 mg/kg. Cardiac arrhythmias were induced in 100% animals.
View Article and Find Full Text PDFClassification of antiarrhythmic drugs was proposed by E. Williams and updated by D. Harrison in those days when antiarrhythmic activity of activators of the heart's receptors and ionic pumps was studied hardly at all and effect on the sarcolemma's bilipid layer, permiability was not regarded as a method of correction of bioelectrical instability of the myocardium.
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