[Persistence of chronic inflammatory responses, role in the development of chronic pancreatitis, obesity and pancreatic cancer].

The purpose of the review--to analyze the basic data of the role of chronic low-intensity inflammatory response as general biological process in the development and progression of chronic pancreatitis, obesity, and pancreatic cancer. Highlighted evidence from epidemiological studies showing that chronic pancreatitis and obesity are independent risk factors for pancreatic cancer, regardless of diabetes. Studied role of adipokines as Cytokines regulating of immune inflammatory response.

[Pancreas at metabolic syndrome].

Authors showed the possible role of the pancreas namely in chronic pancreatitis (CP) in development of metabolic syndrome (MS). Apportionment of the basic clinical syndromes which cause development, both MS, and CP is important. There was noticed that pathogenetic approach to therapy of MS should be cased on understanding of pathogenetic contribution of pancreas functional condition to metabolic changes.

[Use of erbisol in chronic pancreatitis, depending on treatment options and concurrent ischemic heart disease in old and senile persons].

In old and senile persons, chronic pancreatitis is known to be accompanied by an uncontrolled intensification of process of free-radical lipid oxidation and inhibition of mechanisms of antiradical defence. The use of erbisol in the instituted therapeutic complex has been found to raise the efficiency of the system of glutathione and glutathione-dependent enzymes, to effect the inhibition of process of free-radical oxidation, improvement of conditions under which the synthesis of reduced glutathione is normally seen to proceed, realization of antiperoxide, disulphide reductase- and ribonucleotide reductase functions of the system as a whole. Moreover, there gets improved the incretory and exacrinous functions of the pancreas.