[Production and properties of polymer composition containing lysozyme and protease C].

Conditions of the obtaining polymer compositions, containing protease C, lysozyme and polysacharide sodium alginate and their properties were developed and investigated. The effect of compositions content on properties of immobilized enzymes were demonstrated.

[Production of fibrous materials, containing an immobilized proteolytic enzyme and urea].

Immobilization of cellulose and polyacrylic acid on a grafted copolymer increased significantly the stability of proteolytic enzymes to inactivation by urea. Materials containing immobilized proteolytic enzymes and urea and displaying a combined biological activity were obtained.

[Coimmobilization on unmodified polymers of the proteolytic enzyme protease S and antimicrobial drugs].

In order to develop materials of prolonged biological effects, the proteolytic enzyme protease S was coimmobilized with antimicrobial drugs chlorhexidine bigluconate and gentamicin sulfate on unmodified cellulose and polyester fibrous materials. The drugs were incorporated into the polymeric composition, which was attached to the materials studied.

[Coimmobilization of proteolytic and bacteriolytic enzymes and properties of isolated materials].

Coimmobilization of proteolytic and bacteriolytic enzymes on a carboxyl-containing grafted cellulose copolymer was studied. The resistance of lysozyme to gamma-sterilization significantly increased after coimmobilization with a proteolytic enzyme. The resulting material accelerated the cleansing of wounds.

[Preparation of films with combined biological activity and study of their properties].

Joint immobilization of a proteolytic enzyme (terrilytin, protease C, or collytin) and an antimicrobial compound or the bacteriolytic enzyme lysozyme in the structure of polyvinyl alcohol was studied. Changes in the activity of immobilized enzymes upon x-ray sterilization were studied. These materials were highly effective in wound healing.