Lived experiences of life with newly diagnosed advanced cancer - a qualitative interview study.

Background: Incurable cancer significantly affects an individual's life, requiering comprehensive palliative care (PC). With early PC now recommended but poorly integrated, it is essential to address patients' experiences and concerns to ensure successful early PC integration.

Aim: This study aims to investigate the experiences of life in the initial period following a diagnosis of incurable cancer to inform early PC integration.

A Manufacturing Technique for Binary Clathrate Hydrates for Cold and Very Cold Neutron Production.

Intense sources of very cold neutrons (VCNs) would be beneficial for various neutron scattering techniques and low-energy particle physics experiments. Binary clathrate hydrates hosting deuterated tetrahydrofuran (THF-d) and dioxygen show promise as potential moderators for such sources due to a rich spectrum of localized low-energy excitations of the encaged guest molecules. In this article, we present a reliable manufacturing technique for such hydrates.

A Proof-of-Concept for Safety Evaluation of Inhalation Exposure to Known Respiratory Irritants Using In Vitro and In Silico Methods.

There is increased interest in developing non-animal test systems for inhalation exposure safety assessments. However, defined methodologies are absent for predicting local respiratory effects from inhalation exposure to irritants. The current study introduces a concept for applying in vitro and in silico methods for inhalation exposure safety assessment.

A prospective study of methylated ctDNA in patients undergoing treatment for liver metastases from colorectal cancer.

Background: Decision regarding local treatment of colorectal liver metastases (CRLM) is a multidisciplinary assessment, and liver intervention should be performed when the metastases are deemed resectable. There is no standard biomarker to aid neither this decision nor the postoperative treatment decisions. The present prospective, observational study aimed to investigate the potential clinical utility of a combined tumor-specific and organ-specific methylated circulating DNA assay in the perioperative setting of CRLM.