[Prevalence of the intestinal variant in multiorgan atherosclerosis: difficulties of the clinical diagnosis].

One case of multiorgan atherosclerosis with prevalence of atherosclerotic clinical manifestations of the mesenteric arteries with their thrombosis and intestinal infarct is reported. The diagnosis was established only in the final stage of the disease.

[Xanthogranulomatous pyelonephritis].

Based on the evidence obtained on 28 cases of xanthogranulomatous pyelonephritis (XP), the authors suggest to distinguish two XP clinical forms: obstructive and nonobstructive. The former may occur in noticeable destruction of renal tissue and urine retention secondary, most frequently, to long-standing nephrolithiasis. The latter simulates by symptoms and examination results renal carcinoma.

[Morphologic characteristics of nephrosclerosis: electron microscopic, immunohistochemical and histospectrophotometric study].

Combined study of nephrosclerosis revealed profound alterations of both extracellular matrix (ECM) and tubular epithelium. ECM alterations manifested in the accumulation in the stroma of I and III types of collagen, fibronectin, considerable increase of collagen IV and laminin.

[Sclerosis and carcinogenesis].

Morphological analysis of the sclerotic changes in peripheral lung carcinoma (PLC) and nephrosclerosis in renal-cell carcinoma (RCC) established a promoting role of sclerosis in carcinoma development. The pneumosclerosis role as a background process in the PLC development is proved by the following facts: high proportion (83%) of the carcinoma in the scar among PLC; identity of the scar collagen composition in PLC and that in metatuberculosis and metapneumonic pneumosclerosis foci; detection of metatuberculosis foci in 75% of PLC; the presence of the precancerous changes in the epithelium entrapped in the pneumosclerotic foci, not only with signs of morphological atypia, but with the disturbance of nuclear DNA and cellular oncogene expression as well. The association of RCC with nephrosclerosis is shown by a high proportion (82.