Fatty acid synthase inhibition improves hypertension-induced erectile dysfunction by suppressing oxidative stress and NLRP3 inflammasome-dependent pyroptosis through activating the Nrf2/HO-1 pathway.

Background: Erectile dysfunction (ED) is a prevalent male sexual disorder, commonly associated with hypertension, though the underlying mechanisms remain poorly understood.

Objective: This study aims to explore the role of Fatty acid synthase (Fasn) in hypertension-induced ED and evaluate the therapeutic potential of the Fasn inhibitor C75.

Materials And Methods: Erectile function was assessed by determining the intracavernous pressure/mean arterial pressure (ICP/MAP) ratio, followed by the collection of cavernous tissue for transcriptomic and non-targeted metabolomic analyses.

Immune cells: Mediators in the metabolites and Alzheimer's disease.

Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder that predominantly affects elderly individuals across the globe. While genetic, environmental, and lifestyle factors are known to influence the onset of AD, the underlying mechanisms remain unclear.

Objective: To elucidate the intricate interplay between metabolites and immune cell activation in the ethology of AD, and to determine their collective impact on AD risk.

Proteo-Transcriptomic Analysis Reveals the Mechanisms Underlying Escherichia coli Phenotypic Shifts Under Blue Light.

Bacteria can adapt their lifestyles, including microbial growth, metabolism, and biofilm formation, in response to light signaling. However, the molecular pathways through which blue light affects the lifestyle of Escherichia coli (E. coli) remain incomplete and poorly understood.

Effect of NaCl on the modulation of LPFG double peak by PDDA/PSS nanomembrane.

In this paper, poly(diallyldimethylammonium chloride)(PDDA)/poly(sodium styrene sulfonate)(PSS) nanomembranes were deposited on the surface of long-period fiber gratings (LPFG) using the electrostatic layer-by-layer (LBL) assembly method, and the effect of NaCl on the modulation of LPFG double peaks by PDDA/PSS nanomembranes was investigated. The principle behind the emergence of double peaks was first explored using coupled mode theory, revealing that changes in the mode effective refractive index(RI) occur as the number of nanomembrane layers increases. The experimental results showed that under the conditions of PDDA with NaCl/PSS without NaCl and PDDA without NaCl/PSS with NaCl, double peaks do not appear in the spectra of LPFG as the number of thin film layers increases.