[Effect of pantothenate on indices related to cobalamin metabolism in vitamin B 12 deficiency].

White rats kept on the B12-deficient diet for 9 weeks developed hyperchromic anemia, manifested the reduced content of cobalamines in the blood, kidneys, liver, myocardium and urine, the increased excretion of methylmalonic acid (MMA) and the intensified activity of CoA and its precursors participating in the reaction of acetylation in the liver, kidneys and myocardium. There was a decrease in the content of cobalamine-protein complexes that break down to the greatest extent at 80 degrees C. Ten-fold administration of cyanocobalamine (0.

[Peculiar features of the effect of cobalamines on the metabolism of vitamin B 12 and pantothenic acid in B 12 deficiency].

A single parenteral administration to B12-deficient rats of cyan cobalamine (CN-Cbl), oxycobalamine (OH-Cbl), methyl cobalamine (CH3-Cbl) and adenosyl cobalamine (Ado-Cbl) at a dose of 100 microgram/kg body weight increased the lowered level of total cobalamines in the liver to reach or exceed the norm. The study of cobalamine-protein complexes (CPC) in the liver of B12-deficient rats showed that the content of free cobalamines and CPC was decreased, the level of CPC degrading at 80 degrees C being particularly low. An administration of OH-Cbl and CH3-Cbl raised significantly the content of CPC degrading at 80 degrees C and presumably containing Ado-Cbl.