Diversity in crisis: The impact of race and ethnicity on failure to rescue among geriatric trauma patients over the years.

Background: Failure to rescue (FTR) is an indicator of the quality of care provided by trauma centers. The aim of this study was to examine the trends of FTR incidence in geriatric trauma patients over the years and to determine whether race, ethnicity, and sex impact the FTR incidence.

Methods: This is a retrospective analysis of the American College of Surgeons Trauma Quality Improvement Program database over 4 years (2017-2020).

Adenoviral-vectored neoantigen vaccine augments hyperexpanded CD8 T cell control of tumor challenge in mice.

Background: Neoantigens are promising immunogens for cancer vaccines and are often delivered as adjuvanted peptide vaccines. Adenoviral (Ad) vectors have been shown to induce strong CD8 T cell responses as vaccines against SARS-CoV-2, Ebola, and Zika, but their utility as neoantigen delivery vectors remains largely unexplored. In this study, we examine how an Ad-vectored neoantigen vaccine would impact tumor immunity compared with a peptide neoantigen vaccine.

Co-encapsulation of vitamins B6 and B12 using zein/gum arabic nanocarriers for enhanced stability, bioaccessibility, and oral bioavailability.

The present study aimed to fabricate a co-deliver system using zein/gum arabic (GA) polymers for enhanced stability and bioavailability of vitamins (B6 and B12). The anti-solvent evaporation method was used for the preparation of PC-ZG NPs (pyridoxine-cyanocobalamin zein-GA nanoparticles). The process conditions were statistically optimized using the design of Box-Behnken.

Linear prediction on Cent scale for fundamental frequency analysis.

Understanding the fundamental frequency and harmonic content of audio signals is crucial for many applications in music analysis, including music transcription, audio synthesis, and genre identification. This study formulates a signal processing approach combining Linear Prediction (LP) analysis and the Cent scale to accurately characterize the pitch and harmonic structure of the audio signals. Pitch tracking on the LP spectrum in the Cent scale provides more accurate and reliable pitch estimation, especially in the presence of noise or overlapping harmonics.