Publications by authors named "T Murali"
: metabolic allies and adversaries in the world of polymicrobial infections.
Crit Rev Microbiol
September 2024
(PA), an opportunistic human pathogen that is frequently linked with chronic infections in immunocompromised individuals, is also metabolically versatile, and thrives in diverse environments. Additionally, studies report that PA can interact with other microorganisms, such as bacteria, and fungi, producing unique metabolites that can modulate the host immune response, and contribute to disease pathogenesis. This review summarizes the current knowledge related to the metabolic interactions of PA with other microorganisms (, , , , and ) and human hosts, and the importance of these interactions in a polymicrobial context.
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- Network biology is an interdisciplinary field that combines computational and biological sciences to improve understanding of cellular functions and diseases, though it is still a developing area after two decades.* -
- The field faces challenges due to the increasing complexity and diversity of biological data, but active research areas include molecular networks, patient similarity networks, and machine learning applications.* -
- The article provides an overview of recent advancements, highlights future directions, and emphasizes the need for diverse scientific communities and educational initiatives within network biology.*
Melanins are heterogenous biopolymers produced by many macro and microorganisms. They enhance the ecological fitness of the producer organisms by improving their virulence and protecting them from radiation, osmotic and heat stresses. Fungi synthesise either DOPA or DHN melanin and deposit them on their cell walls.
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- Calcinosis cutis is a skin condition marked by the presence of calcified lesions, with idiopathic calcinosis cutis being a rare subtype that lacks a known cause.
- The condition has been observed in various body areas, but only five cases involving the hands have been documented.
- A case study highlights the successful surgical removal of calcified lesions in a 65-year-old man, suggesting that this treatment is effective for idiopathic calcinosis cutis in the hands.
Article Synopsis
- - Microbial interactions are essential in ecosystems, categorized as positive, negative, or neutral, helping to understand the roles of different microbial species
- - The review highlights methods for studying these interactions, including qualitative techniques like co-culturing with microscopy and multi-omics data, as well as quantitative methods like network analysis and synthetic microbial consortia
- - Understanding these interactions can lead to insights for tackling infections caused by harmful microbes and can enhance our knowledge of complex, less-explored ecosystems.