Generation of a SARS-CoV-2-susceptible mouse model using adenovirus vector expressing human angiotensin-converting enzyme 2 driven by an elongation factor 1α promoter with leftward orientation.

Introduction: To analyze the molecular pathogenesis of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a small animal model such as mice is needed: human angiotensin converting enzyme 2 (hACE2), the receptor of SARS-CoV-2, needs to be expressed in the respiratory tract of mice.

Methods: We conferred SARS-CoV-2 susceptibility in mice by using an adenoviral vector expressing hACE2 driven by an elongation factor 1α (EF1α) promoter with a leftward orientation.

Results: In this model, severe pneumonia like human COVID-19 was observed in SARS-CoV-2-infected mice, which was confirmed by dramatic infiltration of inflammatory cells in the lung with efficient viral replication.

The association between interoception and olfactory affective responses.

Odors are known to affect an individual's emotions and physiological states. Recent research has revealed that olfaction is linked to the mental representation of internal sensations, known as interoception. However, little research has examined how interoception relates to emotional responses to odors.

Relationships between subjective experience, electroencephalogram, and heart rate variability during a series of cosmetic behavior.

Introduction: Cosmetic behavior is an important daily activity, especially for women, because it increases visual attractiveness, self-confidence, and positive emotions. However, it is unknown whether a relationship exists between physiological measures and subjective experiences during the series of cosmetic behaviors.

Methods: Electroencephalograms (EEG) and electrocardiograms (ECG) from thirty female participants who were asked to look in a mirror after applying skincare, as well as base, eye, cheek, and lip makeup were recorded.

Investigating the effects of weather on headache occurrence using a smartphone application and artificial intelligence: A retrospective observational cross-sectional study.

Objective: To investigate the relationship between weather and headache occurrence using big data from an electronic headache diary smartphone application with recent statistical and deep learning (DL)-based methods.

Background: The relationship between weather and headache occurrence remains unknown.

Methods: From a database of 1 million users, data from 4375 users with 336,951 hourly headache events and weather data from December 2020 to November 2021 were analyzed.

An attenuated vaccinia vaccine encoding the severe acute respiratory syndrome coronavirus-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human angiotensin-converting enzyme 2 transgenic mice from severe acute respiratory syndrome coronavirus-2 and its variants.

As long as the coronavirus disease-2019 (COVID-19) pandemic continues, new variants of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) with altered antigenicity will emerge. The development of vaccines that elicit robust, broad, and durable protection against SARS-CoV-2 variants is urgently required. We have developed a vaccine consisting of the attenuated vaccinia virus Dairen-I (DIs) strain platform carrying the SARS-CoV-2   gene (rDIs-S).