Objectives: The impact of food on relapse in ulcerative colitis has not been clearly defined. The aim of this prospective, randomized-controlled study was to evaluate the impact of comprehensive dietary guidelines on the clinical course of the disease and quality of life in patients with ulcerative colitis.
Materials And Methods: Patients were allocated randomly to an intervention or a control group.
Background: Up to 40% of patients with ulcerative colitis (UC) fail to comply with 5-aminosalicylic acid (5-ASA) therapy. This study aimed to evaluate multifaceted adherence-enhancing interventions for oral 5-ASA therapy in UC and consider changes in health beliefs and satisfaction with information.
Methods: Adults attending a UK gastroenterology outpatient clinic were recruited to an exploratory randomized controlled trial.
Background: The potential for metronidazole 10 per cent ointment to exert therapeutic benefit in perianal Crohn's disease, while minimizing the adverse effects found with oral metronidazole, was evaluated in a randomized placebo-controlled study.
Methods: Subjects with perianal Crohn's disease were randomized to metronidazole 10 per cent ointment, 0.7 g applied perianally three times daily, or placebo ointment.
Background: Non-adherence to 5-aminosalicylic acid (5-ASA) medication can limit the established benefits of this therapy in ulcerative colitis (UC).
Aim: To determine rates and predictors of non-adherence to 5-ASA therapy in UC patients.
Methods: Medication adherence was assessed using self-report data and urinary drug excretion measurements.