Inhaled turmerone can attenuate nicotine-induced degeneration of the aorta.

Nicotine in secondhand smoke can increase the risk of development of cardiovascular disease in passive smokers through degeneration of the aorta which is one of main pathologies of cardiovascular disease. We speculated that the adverse effect of nicotine can be attenuated by volatile active molecules. As the potential molecule having vasoprotective effect, we focused on turmerone which is major volatile compound in turmeric (Curcuma longa).

3-Keto-indazole derivatives exhibiting multi-coloured phosphorescence.

To advance the development of luminescent materials based on indazoles, a class of nitrogen-containing aromatic compounds, it is crucial to establish a reliable synthetic method for their derivatives. Five 1-indazole derivatives with a ketoaryl group at the 3-position were synthesized by a cyclisation reaction using phenyltriazene derivatives. In solution state, only 3-ketoindazole derivatives bearing 4-diphenylaminophenyl or pyrenyl groups showed fluorescence at room temperature, whereas all 3-ketoindazole derivatives showed blue, green, or red phosphorescence, depending on the substituents, at 80 K.

Endoscopic features of solitary colorectal hamartomatous polyps: Solitary juvenile polyp and Peutz-Jeghers polyp.

Background And Study Aims: The aim of this study was to clarify the endoscopic characteristics of colorectal hamartomatous polyps, including solitary juvenile polyp (JP) and solitary Peutz-Jeghers polyp (PJP).

Patients And Methods: We reviewed the clinicopathological and endoscopic findings of 151 colorectal polyps with a diagnosis of solitary JP or solitary PJP. The clinicopathological and endoscopic findings of 119 JPs and 32 PJPs were retrospectively compared.

Association Between Phase Angle and Tongue Pressure in Older Inpatients with Connective Tissue Diseases.

To investigate the association between tongue pressure (TP) and phase angle (PhA) in patients with connective tissue diseases (CTDs) aged 65 years or older. This retrospective cross-sectional study was conducted on 189 patients with CTDs who underwent hospital rehabilitation. TP was measured using a tongue pressure measuring device, and PhA was calculated from the bioimpedance analysis readings.

DNTT-mediated DNA damage response drives inotuzumab ozogamicin resistance in B-cell acute lymphoblastic leukemia.

Inotuzumab ozogamicin (InO) is an antibody-calicheamicin conjugate with striking efficacy in B-cell acute lymphoblastic leukemia (B-ALL). However, there is wide interpatient variability in treatment response, and the genetic basis of this variation remains largely unknown. Using a genome-wide CRISPR screen, we discovered that the loss of DNA nucleotidylexotransferase (DNTT) is a primary driver of InO resistance.