Publications by authors named "T Morimura"

Article Synopsis
  • Mislocalization and aggregation of the TDP-43 protein in the cytoplasm are key features of ALS and FTLD, but their exact roles in these diseases are not fully understood.* -
  • The study uses transgenic mice models to investigate TDP-43 with defective nuclear localization signals and those prone to aggregation, finding that even low levels of aggregated TDP-43 can lead to significant cellular changes like increased phosphorylation and astrogliosis.* -
  • Although both mouse models show enhanced exploratory behavior without locomotor dysfunctions, the presence of aggregated TDP-43 is linked to more severe effects in certain brain areas, suggesting its aggregation propels some disease-related processes, but may not be the main driver of the
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Genetic mutations in fused in sarcoma (FUS) cause amyotrophic lateral sclerosis (ALS). Although mitochondrial dysfunction and stress granule have been crucially implicated in FUS proteinopathy, the molecular basis remains unclear. Here, we show that DHX30, a component of mitochondrial RNA granules required for mitochondrial ribosome assembly, interacts with FUS, and plays a crucial role in ALS-FUS.

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DNA double-strand break (DSB) is the most severe form of DNA damage and accumulates with age, in which cytoskeletal proteins are polymerized to repair DSB in dividing cells. Since tau is a microtubule-associated protein, we investigate whether DSB is involved in tau pathologies in Alzheimer's disease (AD). First, immunohistochemistry reveals the frequent coexistence of DSB and phosphorylated tau in the cortex of AD patients.

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Nuclear lamina is a fundamental structure of the cell nucleus and regulates a wide range of molecular pathways. Defects of components of the nuclear lamina cause ageing-like physiological disorders, called laminopathy. Generally, ageing and diseases are often associated with perturbation of various time-of-day-dependent regulations, but it remains elusive whether laminopathy induces any changes of the circadian clock and physiological rhythms.

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Article Synopsis
  • * A ring-shaped culture vessel was found to produce smaller, more uniform hiPSC aggregates compared to other suspension culture systems, enhancing mass transfer for essential biochemical exchanges.
  • * Different culture systems led to varying differentiation tendencies of the aggregates, with smaller ones favoring ectodermal and mesodermal lineages, while larger aggregates leaned towards endodermal lineage, indicating the influence of aggregate size on stem cell differentiation.
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