Publications by authors named "T Morihana"
Objectives: The aim of this study was to explore the origin of the PenA mosaic amino acid sequence in the ceftriaxone-resistant Neisseria gonorrhoeae FC428 clone.
Methods: The penA sequences of 27 Neisseria subflava pharyngeal isolates were determined by the Sanger method and penA sequences of 52 isolates from nine Neisseria species were obtained from the NCBI database. Comparative analysis of each PenA sequence was performed by multiple sequence alignment using ClustalW.
Objectives: It is shown that eliminating hearing loss in mid-life may reduce the risk for deterioration in cognitive function. Cochlear implantation (CI) is the only available therapy that can eliminate hearing loss in patients who suffer from profound sensorineural hearing loss. This suggests there may be positive effects of hearing level on cognition in older adults following CI.
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- The study is the first of its kind in Japan, surveying antimicrobial susceptibility in 246 samples from patients with various odontogenic infections, revealing high positivity rates for bacterial growth across four infection groups.
- Streptococcus spp. and anaerobic bacteria were the main isolates, with notable resistance in Prevotella spp. to certain antibiotics due to β-lactamase production, though no resistance was found against carbapenems or metronidazole.
- Sensitivity testing indicated that while penicillins and cephems were generally effective, Prevotella spp. required combination therapy involving β-lactamase inhibitors for better treatment outcomes.
Osteoclasts Modulate Bone Erosion in Cholesteatoma via RANKL Signaling.
J Assoc Res Otolaryngol
October 2019
Cholesteatoma starts as a retraction of the tympanic membrane and expands into the middle ear, eroding the surrounding bone and causing hearing loss and other serious complications such as brain abscess and meningitis. Currently, the only effective treatment is complete surgical removal, but the recurrence rate is relatively high. In rheumatoid arthritis (RA), osteoclasts are known to be responsible for bone erosion and undergo differentiation and activation by receptor activator of NF-κB ligand (RANKL), which is secreted by synovial fibroblasts, T cells, and B cells.
View Article and Find Full Text PDFWe investigated fibroblast growth factor 12 (FGF12) as a transcript enriched in the inner ear by searching published cDNA library databases. FGF12 is a fibroblast growth factor homologous factor, a subset of the FGF superfamily. To date, its localisation and function in the inner ear have not been determined.
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