Publications by authors named "T Molden"
Article Synopsis
- Lyme borreliosis (LB) is the most prevalent tick-borne disease in Europe, particularly in southern coastal Norway, where it often presents as erythema migrans and can lead to severe complications like Lyme neuroborreliosis or arthritis.
- From 2012 to 2022, the incidence of reported laboratory-confirmed disseminated LB cases in Norway increased by 78%, highlighting the growing concern over this disease.
- A study estimated that the symptomatic LB cases in adults ranged from 315-630 per 100,000 in five southern coastal counties in 2022, indicating a significant underreporting in public health surveillance where only 24-48 symptomatic cases were documented for each reported case.
Article Synopsis
- Pneumococcal conjugate vaccines (PCVs) have shown effectiveness against invasive pneumococcal disease (IPD) in children and older adults, but long-term data on their impact in the elderly across different countries is limited.
- Researchers analyzed IPD incidence among those aged 65+ in Denmark, Finland, Norway, and Sweden over ten years, finding varying cases linked to different PCVs used in pediatric immunization programs.
- Results indicated a decline in IPD incidence in Denmark and Norway, while Sweden and Finland showed no significant changes, highlighting ongoing challenges with vaccine coverage and increasing cases caused by emerging serotypes despite pediatric vaccination efforts.
Biological nanoparticles, such as exosomes, offer an approach to drug delivery because of their innate ability to transport biomolecules. Exosomes are derived from cells and an integral component of cellular communication. However, the cellular cargo of human exosomes could negatively impact their use as a safe drug carrier.
View Article and Find Full Text PDFDNA-based computers can potentially analyze complex sets of biological markers, thereby advancing diagnostics and the treatment of diseases. Despite extensive efforts, DNA processors have not yet been developed due, in part, to limitations in the ability to integrate available logic gates into circuits. We have designed a NAND gate, which is one of the functionally complete set of logic connectives.
View Article and Find Full Text PDFExosomes are naturally secreted extracellular bilayer vesicles (diameter 40-130 nm), which have recently been found to play a critical role in cell-to-cell communication and biomolecule delivery. Their unique characteristics-stability, permeability, biocompatibility and low immunogenicity-have made them a prime candidate for use in delivering cancer therapeutics and other natural products. Here we present the first ever report of echogenic exosomes, which combine the benefits of the acoustic responsiveness of traditional microbubbles with the non-immunogenic and small-size morphology of exosomes.
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