Publications by authors named "T Mohanan Sreenath"

Zellweger Syndrome is a peroxisomal disorder that can lead to elevation of long chain fatty acids and epilepsy, which can be drug resistant. The treatment of drug resistant epilepsy can include the ketogenic diet in appropriately chosen patients. Typically, the ketogenic diet is contraindicated in individuals with defects in fatty acid metabolism because of the diet's reliance on medium and long chain fatty acids.

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The genus Bleeker, 1857 is revised with the description of a new species collected from the gempylidaen fish (Cuvier, 1832) from the southwestern coast of India. A revised generic diagnosis is provided based on the redescription of the type species. (Schioedte and Meinert, 1883) is here synonymised with Bleeker, 1857 based on the original description.

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Dysfunctions of androgen/TGF-β signaling play important roles in prostate tumorigenesis. Prostate Transmembrane Protein Androgen Induced 1 () inhibits androgen and TGF-β signaling via a negative feedback loop. The loss of confers resistance to androgen signaling inhibitors and promotes bone metastasis.

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Article Synopsis
  • Oncogenic activation of the ETS-related gene (ERG), mainly through TMPRSS2-ERG gene fusions, is a common mutation in early prostate cancer that the study focuses on.
  • Researchers screened small-molecule libraries to find an effective inhibitor of the ERG protein and discovered ERGi-USU, which selectively inhibits the growth of ERG-positive cancer cells while sparing normal cells.
  • ERGi-USU shows promising results in combination with enzalutamide and successfully reduced growth in ERG-positive tumor models without toxicity, indicating its potential as a targeted therapy for prostate cancer.
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A correction to this article has been published and is linked from the HTML version of this paper. The error has not been fixed in the paper.

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