HPV Vaccination in a Case of JORRP, a Variety of RRP in Bangladesh Medical College Hospital: A Case Report.

Recurrent respiratory papillomatosis (RRP) is a rare disease which is caused by human papilloma virus (HPV). It is a warty growth in the upper airway may cause significant airway obstruction or voice change. Though it is rare but one with severe morbidity and occasional mortality.

A review of ultraviolet filters and their impact on aquatic environments.

Numerous anthropogenic ultraviolet filters (UVF) have been detected in aquatic environments and concerns have arisen regarding their potential impacts on aquatic organisms. This manuscript reviews the environmental concentrations and potential toxicity of various UVF. The highest concentrations of UVF are typically observed near frequently visited recreational areas and during peak water-activity periods, which suggests that sunscreen application correlates with noticeable alterations in UVF concentrations.

Dorzolamide intermediates with potential anti-inflammatory activity.

Dorzolamide (DZD), a Carbonic anhydrase (CA) inhibitor clinically used to lower intraocular pressure, exhibits anti-inflammatory effects owing to the drug's ability to inhibit the TIR domain-containing adaptor protein (TIRAP)-mediated signalling in macrophages. Here, we investigated whether DZD intermediates also demonstrate any anti-inflammatory property like DZD but with a reduced inhibition of CA. We found that several intermediates of DZD show increased binding to TIRAP at the common interface of kinases, such as Protein kinase C-delta (PKCδ) and Bruton's tyrosine kinase (BTK).