Publications by authors named "T Mizunoe"
Article Synopsis
- Researchers established the context of diagnosing organ dysfunction from massive hemorrhage, particularly related to childbirth, using a dataset of 107 cases with significant blood loss collected in Japan.
- Out of these cases, 23 patients exhibited low fibrinogen levels, indicating potential coagulation failure, with hematuria present in a few of them.
- Employing machine learning techniques, the study identified critical thresholds in coagulation factors, particularly the relationship between fibrinogen and fibrin degradation products (FDP), to help distinguish cases of hematuria linked to organ dysfunction during significant blood loss in deliveries.
Objective: To clarify the frequency of deficient mismatch repair (dMMR) in Japanese ovarian cancer patients, we examined microsatellite instability (MSI) status and immunohistochemistry (IHC) subtypes, including endometrioid carcinoma (EMC), clear cell carcinoma (CCC), or a mixture of both (Mix).
Methods: We registered 390 patients who were diagnosed with EMC/CCC/Mix between 2006 and 2015 and treated at seven participating facilities. For 339 patients confirmed eligible by the Central Pathological Review Board, MSI, IHC, and MutL homolog 1 methylation analyses were conducted.
Aim: To investigate the feasibility of a novel method using artificial intelligence (AI), in which the fibrinogen criterion was determined by the quantitative relation between the distributions of fibrin/fibrinogen degradation products (FDPs) and fibrinogen.
Methods: A dataset of 154 deliveries comprising more than 2000 g of blood lost due to hemorrhage, excluding disseminated intravascular coagulation (DIC), among patients from eight national perinatal centers in Japan from 2011 to 2015 were obtained. The fibrinogen threshold criterion was identified by using the function that best fit the distributions of FDP as determined by AI.
Aim: To investigate whether high-intensity breastfeeding (HIB) reduces insulin resistance during early post-partum period in women with gestational diabetes (GDM), independent of post-partum weight change (PWC).
Materials And Methods: In this multicentre prospective study, we included Japanese women with GDM who underwent a 75-g oral glucose tolerance test (OGTT) during early post-partum. We measured plasma insulin during OGTT to obtain a homeostasis model of assessment of insulin resistance (HOMA-IR).