Publications by authors named "T Miyagi"
Arthritis is one of the most common symptoms of Behcet's Disease (BD) observed in 57% of Japanese patients with BD. The relationship between arthritis and other clinical symptoms of BD and the impact of arthritis on the quality of life (QOL) of patients with BD are still unclear. Therefore, the current study aimed to clarify the differences in clinical symptoms depending on the presence or absence of arthritis and evaluate the impact of arthritis on QOL in these patients.
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- Clinical trials often leave out elderly patients, leading to limited safety and efficacy data for biologics in this demographic.
- A study comparing elderly (≥65 years) and younger (<65 years) patients using data from the West Japan Psoriasis Registry found that treatment-ending adverse events were more common in the elderly, and malignant neoplasms occurred at higher rates.
- Despite some safety concerns, biologics were effective for both age groups, with no significant differences in treatment outcomes or quality of life indicators between the elderly and younger patients.
Rationale: Since the precise mechanisms of posttraumatic stress disorder (PTSD) remain unknown, effective treatment interventions have not yet been established. Impaired extinction of fear memory (EFM) is one of the core symptoms of PTSD and is associated with stress-induced epigenetic change in gene expression.
Objectives: In this study, we examined whether the involvement of histone H3 lysine 9 dimethylation (H3K9me2) in EFM is mediated through brain-derived neurotrophic factor (BDNF) expression in the hippocampus, and whether BIX01294, a selective G9a and GLP histone methyltransferase inhibitor, could be treatment for impaired EFM in an animal model of PTSD.