A new catalyst-free method has been created for adding carboxyl groups to unactivated alkenes using CO radical anions.
This approach allows for the efficient production of polycyclic indole derivatives and linear carboxylic acids under mild conditions, either with or without the addition of DABCO in DMSO.
This research represents a major advancement in green chemistry, utilizing affordable and easily accessible reagents for functionalizing unactivated alkenes.
- This study examines the gastrointestinal safety of diclofenac sodium when administered via a transdermal patch (DSSP) versus an oral tablet (DST) in patients with low back pain (LBP).
- Results showed that DSSP significantly reduced the incidence of gastroduodenal ulcers and erosions (26.7%) compared to DST (86.2%), demonstrating a -59.5% difference in risk.
- Additionally, no adverse events were reported with DSSP, while 20% of patients using DST experienced mild adverse effects, highlighting DSSP's safety advantage.