In vivo use of human fibrin glue under the subperiosteal and subcutaneous planes in Holtzman rats.

Background: Commercial fibrin sealant has been increasingly used off-label in the United States for aesthetic surgical procedures to minimize postoperative drainage, hematoma and seroma collections, ecchymosis, and edema.

Objective: We sought to determine the optimal concentrations of thrombin and fibrinogen to extend the sealant adhesion time and to maintain the maximal glue strength, respectively, in subperiosteal and subcutaneous planes in Holtzman rats.

Methods: Three preparations of 2-component fibrin sealant from the Hemaseel APR kit (Haemacure Corp.

Lower eyelid hernia repair for palpebral bags: a comparative study.

The standard treatment for herniated "bags" of the lower eyelid is surgical removal of excess fat. Sachs and Bosniak in 1986 and de la Plaza and Arroyo in 1988 described a new technique for treatment of palpebral bags that consisted of returning the herniated fat to the orbital cavity and retaining it by continuous sutures of the capsulopalpebral fascia either to the dehiscent portion of the orbital septum or to the periosteum of the lower orbital rim. This article reports a prospective study of 26 patients who underwent standard blepharoplasty in one lower eyelid and capsulopalpebral fascia hernia repair in the other lower eyelid.

Carbon dioxide laser ablation of anogenital condyloma acuminata in pediatric patients.

The treatment of anogenital condyloma acuminata in pediatric patients is difficult, with a wide range of treatment strategies that yield variable success. Treatment regimens must consider the patient age, and etiology, location, and severity of lesions. We report our experience using the carbon dioxide (CO2) laser to ablate these lesions.

Pharmacology and toxicology of chronically infused epidural clonidine.HCl in dogs.

To evaluate the physiological effects and toxicity of epidural clonidine.HCl, male Beagle dogs were prepared with chronic lumbar epidural catheters and administered constant infusions of either saline (N = 10), or 80 micrograms/hr (N = 6), 200 micrograms/hr (N = 6), or 320 micrograms/hr (N = 12) clonidine.HCl at a rate of 4 ml/24 hr for 28 days.

Toxicology of baclofen continuously infused into the spinal intrathecal space of the dog.

The continuous spinal administration of baclofen has been shown to have therapeutic benefit in the management of spasticity in humans with neuraxial injuries. The present study systematically investigated the potential spinal neurotoxicity of continuous intrathecally-infused baclofen in dogs. Male beagle dogs were prepared with chronic lumbar intrathecal catheters connected to subcutaneously implanted infusion pumps.