Publications by authors named "T Milne"
Aim: To investigate the influence of type 2 diabetes (T2D) and hyperglycaemia on blood vessels and angiogenic markers in the dental pulp.
Methodology: Extracted non-carious permanent molar teeth were collected from patients with well-controlled T2D (n = 10) and non-T2D (controls) (n = 10). The pulp was examined qualitatively using haematoxylin and eosin and Van Gieson stains.
Lead optimisation of OXS007417: PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia.
RSC Med Chem
July 2024
Article Synopsis
- The development of differentiation therapy for Acute Myeloid Leukemia (AML) could significantly enhance patient outcomes globally.
- Our lab has identified a new class of agents that successfully reduce tumors in mouse models.
- We optimized a compound (OXS007417) for better effectiveness and safety, and discovered improved versions (OXS008255 and OXS008474) that showed better pharmacokinetics and delayed tumor growth in tests with HL-60 cells.
B-cell acute lymphoblastic leukemia (B-ALL) is the most common pediatric cancer, with long-term overall survival rates of ∼85%. However, B-ALL harboring rearrangements of the MLL gene (also known as KMT2A), referred to as MLLr B-ALL, is common in infants and is associated with poor 5-year survival, relapses, and refractoriness to glucocorticoids (GCs). GCs are an essential part of the treatment backbone for B-ALL, and GC resistance is a major clinical predictor of poor outcome.
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- The study reviews risk prediction algorithms for prolonged postoperative ileus (PPOI) after colorectal surgery, highlighting their variability and common healthcare impact.
- Eleven studies with a total of 87,549 participants were assessed, mainly consisting of retrospective analyses, with PPOI rates ranging from 10% to 28%.
- The algorithms demonstrated moderate predictive ability (area under the curve of 0.68-0.78), but there was inconsistency in the definition of PPOI used, and minimal validation data was reported.
Chromatin and aberrant enhancer activity in KMT2A rearranged acute lymphoblastic leukemia.
Curr Opin Genet Dev
June 2024
To make a multicellular organism, genes need to be transcribed at the right developmental stages and in the right tissues. DNA sequences termed 'enhancers' are crucial to achieve this. Despite concerted efforts, the exact mechanisms of enhancer activity remain elusive.
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