Impact of long-term trends on outcomes in the management of colonic diverticular bleeding: mediation analyses in a large multicenter study.

Background: Despite accumulating evidence and recommendations for management of colonic diverticular bleeding (CDB), the changes in its clinical management and outcomes remain unknown.

Methods: We performed a retrospective tendency analysis on a biennial basis, a propensity score-matched cohort study between the first and latter half groups, and mediation analyses to compare the diagnostic and treatment methods between January 2010 and December 2019 (CODE BLUE-J Study).

Results: A total of 6575 patients with CDB were included.

An epidemiological study on the factors including genetic polymorphism influencing ALT >30 U/L and liver fibrosis progression in metabolic dysfunction-associated steatotic liver disease among the general population.

Background And Aim: Identifying the factors contributing to the progression of metabolic dysfunction-associated steatotic liver disease (MASLD), a lifestyle-related disease, is crucial for preventing future liver-related deaths. This study aimed to epidemiologically investigate factors, including single-nucleotide polymorphisms (SNPs) associated with alanine aminotransferase (ALT) levels >30 U/L and potential risk factors for liver fibrosis, in a general population cohort of patients with MASLD.

Methods: Among 1059 participants in the health checkup project, 228 who were diagnosed with MASLD were analyzed.

Three-Dimensional Vascular Structure of Caudal and Dorsal Fins of a Dwarf Sperm Whale.

Previous studies have described two distinct vascular systems in cetacean fins. However, these studies have been limited to Delphinoidea species, with little information on their three-dimensional structures. In this study, the anatomical analysis of the caudal and dorsal fins of a dwarf sperm whale was conducted using X-ray computed tomography and gross dissection with staining, providing the first confirmation of the two vascular systems in the fins of the family Kogiidae.

Mid-term outcomes of compaction autologous bone grafting in uncemented primary total hip replacement stems.

Introduction: Fixation and long-term stability of collared, uncemented stems, such as the CORAIL collared stem, in total hip arthroplasty (THA), depend on a strong cancellous bone sleeve and subsequent osseointegration. This study aimed to investigate bone reaction and mid-term outcomes following compaction autologous bone grafting in uncemented stems in primary THA.

Materials And Methods: This study retrospectively reviewed patients with primary THA using CORAIL collared stem and having ≥ 5 years follow-up.

Lower serum uric acid levels are associated with depressive symptoms in a Japanese general population: A population-based cross-sectional study.

Uric acid (UA) is a final product of purine metabolism and has neuroprotective effects. It has not been established whether serum UA levels are associated with depressive disorder. Thus, we investigated whether serum UA levels are associated with depressive symptoms in a Japanese general population.