Linear-Decoupling Enables Accurate Speed and Accuracy Predictions for Copolymerization Processes.

Biological processes exhibit remarkable accuracy and speed and can be theoretically explored through various approaches. The Markov-chain copolymerization theory, describing polymer growth kinetics as a Markov chain, provides an exact set of equations to solve for error and speed. Still, due to nonlinearity, these equations are hard to solve.

Complete genome sequence of phage fHSPT3.

Here, we describe a bacteriophage isolated from sewage water. The phage fHSPT3 was isolated against the host 168 and has a genome size of 150,187 bp with 221 protein-coding sequences. The fHSPT3 belongs to the genus , lacks virulence or antibiotic resistance genes, and shows a virulent life cycle predicted through PhageScope and PhageAI.

Insights into Error Control Mechanisms in Biological Processes: Copolymerization and Enzyme-Kinetics Revisited.

The high fidelity observed in biological information processing ranging from replication to translation has stimulated significant research efforts to clarify the underlying microscopic picture. Theoretically, several approaches to analyze the error rates have been proposed. The copolymerization theory describes the addition and removal of monomers at the growing tip of a copolymer, leading to a closed set of nonlinear equations.

Isolation, Genomic Characterization of Shigella prophage fPSFA that effectively infects multi-drug resistant Shigella isolates from the Indian Poultry Sector.

Because of uncontrolled use of antibiotics, emergence of multidrug-resistant Shigella species poses a huge potential of zoonotic transfer from poultry sector. With increasing resistance to current antibiotics, there is a critical need to explore antibiotic alternatives. Using a Shigella flexneri reference strain, we isolated a novel fPSFA phage after inducing with mitomycin C.

A Randomized Controlled Trial on Comparison of Clinical Outcome in Uncomplicated SAM Managed with and without Antibiotics.

Objectives: To assess the clinical outcome of management of uncomplicated severe acute malnutrition (SAM) at community level with antibiotics vs. without antibiotics.

Methods: A randomized controlled trial was conducted on children aged 6 to 59 mo with uncomplicated SAM, selected randomly from rural areas of Kanpur.