Publications by authors named "T Mechichi"
Antibiotics play a crucial role in human and animal medical healthcare, but widespread use and overuse of antibiotics poses alarming health and environmental issues. Fluoroquinolones constitute a class of antibiotics that has already become ubiquitous in the environment, and their increasing use and high persistence prompt growing concern. Here we investigated a fungal secretome prepared from the white-rot fungus , which is able to effectively degrade the environmentally persistent fluoroquinolone, levofloxacin.
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- A study investigated a white-rot fungus known for its ligninolytic enzymes, focusing on a dye-decolorizing peroxidase (DyP) and its potential to biotransform antibiotics.
- The enzyme was cloned, expressed, and characterized, revealing optimal activity at pH 3 and stability between 30 °C and 50 °C, with the ability to decolorize various industrial dyes.
- Results showed that DyP1 effectively biotransformed several fluoroquinolone antibiotics, highlighting its potential for biotechnological use in environmental applications.
Characterization and biocontrol potential of yeasts isolated from dates: Volatile compounds-mediated antifungal activity against mycotoxigenic strains.
Heliyon
October 2024
Article Synopsis
- * The yeast strains demonstrated resilience, growing in high concentrations of sucrose, salt, and extreme temperatures, and showed significant inhibition of mycotoxigenic species that affect dates, with inhibition percentages between 43.6% and 70.3%.
- * The strains produced volatile compounds that effectively inhibited fungal growth and sporulation, indicating their potential as a safe and eco-friendly alternative to synthetic fungicides for protecting stored dates.
Continued widespread use of antibiotics, especially fluoroquinolones, raises environmental concerns, as its driving bacterial resistance and disrupts microbial ecosystems. Here we investigate the biodegradation of ten fluoroquinolone antibiotics (six for medical use and four for veterinary use) by ligninolytic fungi, including , , , , , , , , and . The results show significant variations between strains in the efficiency of antibiotic transformation.
View Article and Find Full Text PDFDue to widespread overuse, pharmaceutical compounds, such as antibiotics, are becoming increasingly prevalent in greater concentrations in aquatic ecosystems. In this study, we investigated the capacity of the white-rot fungus, (a high-laccase-producing fungus), to biodegrade ampicillin under different cultivation conditions. The biodegradation of the antibiotic was confirmed using high-performance liquid chromatography, and its antibacterial activity was evaluated using the bacterial growth inhibition agar well diffusion method, with as an ampicillin-sensitive test strain.
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