Collaboration Across Disciplines to Integrate Clinical Expertise into Medical Software Development: The Approach of the Dedalus Medical Office.

Medical informatics is a multidisciplinary field combining clinical and technical expertise. Addressing the challenge of aligning software design with clinicians' real-world needs, Dedalus established the Medical Office, a dedicated department designed to integrate clinical expertise directly into the software development process, in 2022. This paper details the approach and impact of the Medical Office.

Human retrograde amnesia and memory consolidation.

This paper reports a reassessment of published literature on the question of whether retrograde amnesia data from patients with severe trauma supports the idea that there is ongoing consolidation of long-lasting memories. That is, memory consolidation continues for decades with older memories being increasingly consolidated, and, thus, more protected from forgetting. Our analysis was limited to patients with specific traumas rather than neurodegenerative conditions that can be complicated by the additional presence of significant anterograde amnesia.

Enhancing Clinical Practice: Creating Dynamic Medical Content in Electronic Medical Records.

The integration of Electronic Medical Records (EMRs) revolutionized healthcare but often retained limitations from paper-based structures. This study proposes a framework for developing dynamic medical content specifically adapted to the clinical context including medical specialty and diseases. Tailoring content to this dynamic context offers several benefits, including improved access to relevant information, streamlined workflows, and potentially better patient outcomes.

Creatine supplementation for optimization of physical function in the patient at risk of functional disability: A systematic review and meta-analysis.

Background: The efficacy of creatine replacement through supplementation for the optimization of physical function in the population at risk of functional disability is unclear.

Methods: We conducted a systematic literature search of MEDLINE, EMBASE, the Cochrane Library, and CINAHL from inception to November 2022. Studies included were randomized controlled trials (RCTs) comparing creatine supplementation with placebos in older adults and adults with chronic disease.

A systematic review and meta-analysis of the clinimetric properties of the core outcome measurement instruments for clinical effectiveness trials of nutritional and metabolic interventions in critical illness (CONCISE).

Background: CONCISE is an internationally agreed minimum set of outcomes for use in nutritional and metabolic clinical research in critically ill adults. Clinicians and researchers need to be aware of the clinimetric properties of these instruments and understand any limitations to ensure valid and reliable research. This systematic review and meta-analysis were undertaken to evaluate the clinimetric properties of the measurement instruments identified in CONCISE.