Publications by authors named "T Matsura"

Background/aim: Persistent hyperglycemia caused by diabetes mellitus is a risk factor for pancreatic cancer (PC). We have previously reported that aberrant activation of atypical protein kinase C (aPKC) enhances PC cell progression. However, no reports have elucidated whether hyperglycemia promotes PC cell progression and whether aPKC activation is related to PC cell progression mechanisms.

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Article Synopsis
  • - The study investigates the differences in cellular uptake of Vitamin E forms, tocopherol (Toc) and tocotrienol (T3), focusing on the role of serum albumin as a contributing factor.
  • - Adding bovine serum albumin (BSA) in serum-depleted media increased T3 uptake while decreasing Toc uptake, showing varying effects among different analogs of both forms.
  • - The research indicates that T3 binds to albumin with a higher affinity than Toc, due to variations in side chains, which influences their cellular uptake mechanisms, offering insights into Vitamin E's physiological roles.
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Background/aim: Surgical treatment of renal cell carcinoma (RCC) with inferior vena cava (IVC) thrombus is associated with high morbidity and mortality rates, therefore presurgical systemic therapies are required in order to improve the safety and feasibility of the surgical procedure by decreasing the thrombus level and burden. The efficacy of presurgical combination therapy of immune checkpoint inhibitors (ICI) and tyrosine kinase inhibitors (TKI) for advanced renal cell carcinoma with IVC thrombus remains unclear.

Case Report: We report a case of a 69-year-old male with cT3bN0M0 locally advanced RCC.

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Pancreatic cancer (PC) is an aggressive malignancy with few treatment options, and improved treatment strategies are urgently required. TYRO3, a member of the TAM receptor tyrosine kinase family, is a known oncogene; however, the relationship between TYRO3 expression and PC chemoresistance remains to be elucidated. We performed gain- and loss-of-function experiments on TYRO3 to examine whether it is involved in chemoresistance in PC cells.

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Coenzyme Q10 (CoQ10) promotes wound healing and . However, the molecular mechanisms underlying the promoting effects of CoQ10 on wound repair remain unknown. In the present study, we investigated the molecular mechanisms through which CoQ10 induces wound repair using a cellular wound-healing model.

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