Publications by authors named "T Matoba"
This study proposed noninvasive machine-learning models for the detection of lesion-specific ischemia (LSI) in patients with stable angina with intermediate stenosis severity based on coronary computed tomography (CT) angiography. This single-center retrospective study analyzed 76 patients (99 vessels) with stable angina who underwent coronary CT angiography (CCTA) and had intermediate stenosis severity (40-69%) on invasive coronary angiography. LSI, defined as a resting full-cycle ratio < 0.
View Article and Find Full Text PDFBackground: Hypertension is a risk factor for bleeding events and is included in the HAS-BLED (Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile INR, Elderly, Drugs/Alcohol concomitantly)score. However, the effects of blood pressure (BP) and changes in BP on bleeding events in patients undergoing percutaneous coronary intervention (PCI) remain poorly understood. This study is aimed to investigate the relationship between systolic BP (SBP) changes during hospitalisation and bleeding events in patients undergoing PCI.
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- - The study focused on myofibroblasts and how a vaccine targeting fibroblast activation protein (FAP) might help reduce cardiac fibrosis in mice with chronic cardiac stress.
- - Mice were vaccinated with a FAP peptide while undergoing continuous treatment with angiotensin II and phenylephrine, resulting in a significant decrease in both cardiac fibrosis and the number of myofibroblasts.
- - The findings suggest that the FAP vaccine is a promising therapeutic option for cardiac fibrosis without causing harmful side effects in other injury models, indicating its potential for future treatments.
Cardiovascular diseases (CVD) have imposed a substantial burden on population health and society. In Japan, the National Plan for the Promotion of Measures Against Cerebrovascular and Cardiovascular Disease, grounded in national legislation, seeks to improve the quality of care and standardize treatment for cerebrovascular disease and CVD. The plan emphasizes the need to develop standardized systems for collecting and disseminating medical information, as well as promoting data-driven research.
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- Polypharmacy, or the use of multiple medications, can increase the risk of adverse events in patients with chronic coronary syndrome (CCS), a group often prescribed many drugs.
- A study involving 1,411 CCS patients found that those taking nine or more medications had a higher incidence of major adverse cardiovascular events (MACE) and overall mortality compared to those on fewer drugs.
- The findings suggest that reducing the number of medications in CCS patients could potentially lower the risk of MACE and all-cause mortality, while still addressing other health conditions.