Machine Learning for Quantitative Prediction of Protein Adsorption on Well-Defined Polymer Brush Surfaces with Diverse Chemical Properties.

Polymer informatics has attracted increasing attention because machine learning can establish quantitative structure-property relationships in polymer materials. Understanding and controlling protein adsorption on polymer surfaces are crucial for various applications, such as protein immobilization supports, biosensors, and antibiofouling surfaces. However, protein adsorption is a complex phenomenon that is difficult to predict quantitatively owing to the involvement of multiple factors.

Serum Soluble Toll-Like Receptor 4 is a Predictive Biomarker for Acute Exacerbation and Prognosis of Idiopathic Pulmonary Fibrosis: A Retrospective Study.

Purpose: Toll-like receptor 4 (TLR4) is a transmembrane receptor promoting pro-inflammatory signalling, that is associated with the pathogenesis of pulmonary fibrosis. TLR4 is abundantly expressed on monocytes and the acceleration of TLR4 signalling induces the secretion of soluble TLR4 isoforms (sTLR4) in circulation. The aim of study was to evaluate the association of serum levels of sTLR4 with acute exacerbation (AE) and prognosis of patients with idiopathic pulmonary fibrosis (IPF).

New functional electronic stimulation device for acute cerebrovascular disorder treatment: A preliminary prospective study.

Objective: Patients with cerebrovascular disease tend to exhibit patterned hemiplegia, such as the Wernicke-Mann posture. Delayed cessation of synkinesis is a major factor impeding hemiplegic recovery; however, effective rehabilitation for acute synkinesis has not been established. This study aimed to evaluate the efficacy and feasibility of a novel treatment using a low-frequency therapeutic device for the cessation of synkinesis in patients with incomplete paralysis and cerebrovascular disease.

Clinical impact of low fornix perfusion on devascularized whole stomach as a risk factor for anastomotic leakage after esophagectomy.

Backgrounds: We previously reported poor vascularity of narrow gastric tube evaluated by thermography was associated with anastomotic leakage (AL) after esophagectomy. Meanwhile, the association between the fornix low perfusion on devascularized whole stomach (DWS) and the incidence of AL remains unclear. Therefore, this study aimed to clarify the impact of the fornix low perfusion on DWS.

A Case of Appendicitis Due to Burkitt Lymphoma Masking the Systemic Symptoms of Rapidly Progressing Burkitt Lymphoma.

Introduction: Primary malignant lymphoma of the appendix is a rare disease, and primary Burkitt lymphoma of the appendix has been reported very rarely in Japan. Burkitt lymphoma is an aggressive lymphoma that progresses more rapidly than other malignant lymphomas, making it sometimes difficult to distinguish between systemic symptoms, such as fever associated with lymphoma progression and fever caused by appendicitis.

Case Presentation: A 21-year-old man underwent open appendectomy after antibiotic treatment for acute appendicitis proved ineffective.