Interspecies differences in the pharmacokinetics of kanamycin and apramycin.

Comparative studies on some selected pharmacokinetic parameters for kanamycin in sheep, goats, rabbits, chickens and pigeons, and for apramycin in sheep, rabbits, chickens and pigeons were carried out after intravenous administration of the two drugs at a dose of 10 mg/kg. The results revealed that a two-compartment open model was most suitable for kanamycin, while for apramycin a one-compartment open model was usually optimal. The log distribution rate constant (alpha) of kanamycin was significantly correlated to the log of the body mass (r = 0.

[Preclinical research on drug forms containing rifamycin SV intended for intramammary use].

It was established, that LD50 of rifamycin SV--sodium salt, produced by the Research Institute on Microbiological Industry--Razgrad (People's Republic of Bulgaria)--RM, at p.o. applying on albino mice, albino rats and broilers is correspondingly greater than 4100.

[Effect of the E-50 Biostimulant on sperm production in young bulls].

The Biostimulant E-50 preparation, a biogenic stumulant, was applied to 8 bulls divided into two groups--with normal and with disturbed semen production (lower qualitative indices of semen and higher number of discarded ejaculates). The stimulant was injected muscularly at the rate of 40 cu. cm, twice, at a seven-day interval, with one of the bulls it being used in a second series.

[Experiments to increase the conception rate in cows with disordered ovulation and spontaneous estrus].

Studied was the time period for the setting in of an ovulation that did not really take place, and the follicular cysts in cows following calving with regard to the effectiveness of the preparation Gn-RH vet. "Berlin-Chemie" in the treatment of the diseased animals. Attempts were made to raise the conception rate of cows manifesting delayed ovulation (with estral and postestral metrorrhagia).