Publications by authors named "T Marchini"
Article Synopsis
- Viral myocarditis involves the immune response to virus invasion, but the role of the GPR15 receptor in heart disease remains unclear.
- Researchers found that mice lacking GPR15 had trouble eliminating coxsackievirus B3, which resulted in harmful heart changes and dysfunction.
- The study suggests that GPR15 is crucial for the timely recruitment of regulatory T cells, and its absence leads to a prolonged inflammatory response and worse cardiac outcomes.
Article Synopsis
- The study aims to understand the immune cell composition in human atherosclerotic plaques, which differs significantly from what is observed in mouse models, often used for research.
- Single-cell RNA sequencing was employed to reveal a diverse immune cell landscape in human plaques, primarily consisting of T-cells, highlighting activation and memory formation that aren't adequately represented in mice.
- The findings suggest that traditional mouse models may not effectively translate to human atherosclerosis, particularly regarding activated T-cell responses, posing questions about their relevance in studying adaptive immune cell behavior.
Middle-age abolishes cardioprotection conferred by thioredoxin-1 in mice.
Arch Biochem Biophys
March 2024
Thioredoxin-1 (Trx1) has cardioprotective effects on ischemia/reperfusion (I/R) injury, although its role in ischemic postconditioning (PostC) in middle-aged mice is not understood. This study aimed to evaluate if combining two cardioprotective strategies, such as Trx1 overexpression and PostC, could exert a synergistic effect in reducing infarct size in middle-aged mice. Young or middle-aged wild-type mice (Wt), transgenic mice overexpressing Trx1, and dominant negative (DN-Trx1) mutant of Trx1 mice were used.
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- Exposure to fine particulate matter (PM) from air pollution leads to respiratory and cardiovascular issues by activating the NLRP3 inflammasome, which triggers inflammation and release of IL-1β, a key inflammatory cytokine.
- The activation of the inflammasome is dependent on the amount and type of PM, with Residual Oil Fly Ash (ROFA) being particularly effective in inducing IL-1β release, while other PM types were less effective.
- The study reveals that mechanisms like lysosomal rupture and mitochondrial dysfunction contribute to IL-1β release, highlighting the complex interplay of cellular damage and immune response to specific air pollutants like ROFA.