Publications by authors named "T Marafioti"
Relapsed/refractory peripheral T cell lymphomas (PTCLs) are aggressive tumors with a poor prognosis. Unlike B cell lymphomas, treatment of PTCL has not benefited from advances in immunotherapy. This is largely due to a lack of suitable target antigens that discriminate malignant from normal T cells, thus avoiding severe immunosuppression consequent to depletion of the entire T cell compartment.
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- Dendritic cells (DC) are essential immune cells that connect the body's innate and adaptive immune responses, with two main types: plasmacytoid DC (pDC) and conventional DC (cDC).
- Research using in vivo deuterium-glucose labeling revealed that a specific subset of cDC known as AXL+ Siglec6+ DC (ASDC) circulates in the bloodstream for about 2.16 days, while other cDC types have slightly shorter lifespans.
- The study also showed that ASDC are quickly recruited to inflamed areas, highlighting their role in managing immune responses during inflammation and suggesting new insights into the behavior of different DC subsets.
Article Synopsis
- Cancer-associated fibroblasts (CAFs) in B-cell precursor acute lymphoblastic leukemia (B-ALL) originate from bone marrow-derived mesenchymal stromal cells (MSCs) and are influenced by reactive oxygen species from chemotherapy.
- The study shows that exposure of MSCs to B-ALL cells or their secretions initiates the CAF formation, marked by a strong interferon pathway response.
- A key finding is that leukemia cell-derived mitochondrial double-stranded RNA (dsRNA) stimulates MSCs to transition into CAFs, and disrupting dsRNA can block this process, revealing a new way cancer cells interact with their environment.