Citronellol Induces Apoptosis via Differential Regulation of Caspase-3, NF-κB, and JAK2 Signaling Pathways in Glioblastoma Cell Line.

Citronellol (CT) is a naturally occurring lipophilic monoterpenoid which has shown anticancer effects in numerous cancerous cell lines. This study was, therefore, designed to examine CT's potential as an anticancer agent against glioblastoma (GBM). Network pharmacology analysis was employed to identify potential anticancer targets of CT.

Selenium treatment via integrating flow electrode capacitive deionization (FCDI) and bio-electrochemical systems (BES).

Selenium pollution in aquatic environments poses a major global challenge, with a significant gap in effective treatment technologies. In this study, we explored a novel approach integrating flow-electrode capacitive deionization (FCDI) with bio-electrochemical systems (BES) for the removal and reduction of selenate and selenite ions in one compact reactor. Our integrated system was electricity-driven, eliminating chemical usage.

Impact on Carbohydrate Metabolism and Oxidative Stress in a Type 2 Diabetic Rat Model.

This study was conducted to assess the possible antidiabetic potential of by employing as well as assessments. The dried plant material was extracted in methanol, ethanol, and water. The in vitro results showed that the ethanolic extract (EthCb) was found to have higher antioxidant and antidiabetic potential as compared with the aqueous (AqCb) and methanolic extracts (MthCb) so it was further evaluated in the in vivo trial using a diabetic rat model.

Optimization of ultrasonically extracted β-sitosterol from using response surface methodology.

genus is recognized as a significant source of β-sitosterol and polyphenols. The inclusion of β-sitosterol into various health-related formulations has widened its potential in the pharmaceutical and nutraceutical industries. Process optimization ensures the maximum efficiency, consistency, and yield.

Anti-Diabetic Activities and Molecular Docking Studies of Aryl-Substituted Pyrazolo[3,4-b]pyridine Derivatives Synthesized via Suzuki Cross-Coupling Reaction.

Pyrazolo[3,4-]pyridine scaffolds have been heavily exploited in the development of nitrogen-containing heterocycles with numerous therapeutic applications in the field of medicinal and pharmaceutical chemistry. The present work describes the synthesis of eighteen biaryl pyrazolo[3,4-]pyridine ester (-) and hydrazide (-) derivatives via the Suzuki cross-coupling reaction. These derivatives were subsequently screened for their therapeutic potential to inhibit the diabetic α-amylase enzyme, which is a key facet of the development of anti-diabetic agents.