A genetically engineered parasite vaccine provides protection from controlled human malaria infection.

Genetically engineered live sporozoites constitute a potential platform for creating consistently attenuated, genetically defined, whole-parasite vaccines against malaria through targeted gene deletions. Such genetically attenuated parasites (GAPs) do not require attenuation by irradiation or concomitant drug treatment. We previously developed a (Pf) GAP with deletions in , , and genes (PfGAP3KO) and demonstrated its safety and immunogenicity in humans.

Adolescent Athletes at Risk of Exercise-Induced Bronchoconstriction: A Result of Training or Pre-Existing Asthma?

Exercise may trigger bronchoconstriction, especially in a group of athletes in whom bronchospasm during exercise is reported to occur more frequently than in nonathletes. The aim of this study was to determine the prevalence and environmental risk factors contributing to exercise-induced bronchoconstriction (EIB) in adolescent athletes. A prospective study was conducted among a group of 101 adolescent athletes who underwent spirometry, exercise challenge, fractional exhaled nitric oxide (FeNO) measurements, and allergy assessment.

putEMG-A Surface Electromyography Hand Gesture Recognition Dataset.

In this paper, we present a putEMG dataset intended for the evaluation of hand gesture recognition methods based on sEMG signal. The dataset was acquired for 44 able-bodied subjects and include 8 gestures (3 full hand gestures, 4 pinches and idle). It consists of uninterrupted recordings of 24 sEMG channels from the subject's forearm, RGB video stream and depth camera images used for hand motion tracking.

Beyond Blood Smears: Qualification of 18S rRNA as a Biomarker for Controlled Human Malaria Infections.

18S rRNA is a biomarker that provides an alternative to thick blood smears in controlled human malaria infection (CHMI) trials. We reviewed data from CHMI trials at non-endemic sites that used blood smears and 18S rRNA/rDNA biomarker nucleic acid tests (NATs) for time to positivity. We validated a multiplex quantitative reverse transcription-polymerase chain reaction (qRT-PCR) for 18S rRNA, prospectively compared blood smears and qRT-PCR for three trials, and modeled treatment effects at different biomarker-defined parasite densities to assess the impact on infection detection, symptom reduction, and measured intervention efficacy.