Publications by authors named "T Manickavasagar"
Neurocognitive adverse events (NAEs) have been reported in up to 60% of patients on lorlatinib, a potent central nervous system-active ALK inhibitor. Manifestations may include psychotic, mood, speech, and cognitive symptoms. Current guidance recommends permanent discontinuation of lorlatinib in cases of grade IV NAEs.
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- PD-L1 expression is a key biomarker for predicting the effectiveness of immunotherapy in patients with non-small cell lung cancer (NSCLC), and is linked to glucose metabolism.
- This study analyzed data from 210 patients with resectable NSCLC to see how metabolic parameters from [F]FDG-PET/CT scans relate to PD-L1 expression levels in tumors and lymph nodes.
- Results showed that while certain metabolic scores were higher in patients with PD-L1 expression ≥ 1%, the accuracy of these scores for predicting PD-L1 positivity was only moderate, indicating limited reliability in clinical settings.
Purpose: Interpretability is essential for reliable convolutional neural network (CNN) image classifiers in radiological applications. We describe a weakly supervised segmentation model that learns to delineate the target object, trained with only image-level labels ("image contains object" or "image does not contain object"), presenting a different approach towards explainable object detectors for radiological imaging tasks.
Methods: A weakly supervised Unet architecture (WSUnet) was trained to learn lung tumour segmentation from image-level labelled data.
Background: Carpal tunnel syndrome (CTS) is one of the most common peripheral nerve compressive neuropathies. The clinical symptoms and physical examinations of CTS are widely recognised, however, there is still debate around what is the best approach for assessment of CTS. Clinical assessment is still considered the gold standard, however, controversies do exist regarding the need for investigations such nerve conduction studies (NCS) to aid with management decisions.
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- - The study investigates the expression of HER3 in lung adenocarcinoma, focusing on identifying how it is regulated and its potential role in treatment options.
- - In a sample of 45 patients, HER3 was found to be overexpressed in 42.2% of cases, and this overexpression wasn't explained by copy number variations.
- - The analysis indicates a correlation between HER3 RNA expression levels and MEK activity, suggesting HER3's significance as a therapeutic target due to its frequent overexpression and downstream signaling effects.