Publications by authors named "T Makabe"
Article Synopsis
- - The study analyzed data from the Japan Society of Obstetrics and Gynecology tumor registry from 2012 to 2019 to assess the status and treatment of endometrial cancer in Japan.
- - Out of 82,969 patients, younger patients tended to receive more chemotherapy, while surgical treatments like laparoscopic or robot-assisted surgeries increased annually, with specific diagnoses linked to advanced stages.
- - The findings highlight important trends and clinicopathological details that help inform treatment strategies and improve understanding of endometrial cancer over multiple years.
Article Synopsis
- Cervical conization is a common treatment for cervical intraepithelial neoplasia (CIN) 2/3, but Ho:YAG laser ablation may be a more effective alternative, which this study aimed to explore.
- The study analyzed data from 607 patients who underwent the Ho:YAG laser treatment from June 2012 to November 2021, reporting a 5.6% recurrence rate of CIN2 or higher after two years.
- Age was identified as a significant risk factor for recurrence, while preoperative CIN grade and HPV status did not have a major impact; the postoperative high-risk HPV test proved highly effective for detecting recurrences.
Substantial numbers of variants of unknown significance (VUSs) have been identified in BRCA1/2 through genetic testing, which poses a significant clinical challenge because the contribution of these VUSs to cancer predisposition has not yet been determined. Here, we report 10 Japanese patients from seven families with breast or ovarian cancer harboring the BRCA2 c.7847C>T (p.
View Article and Find Full Text PDFThe purpose of this study was to establish a new mouse model of endometriosis that mimics real-world women's health problems, in which women continue to be affected by endometriosis long before they wish to become pregnant, and to evaluate the impact of "chronic exposure to endometriosis" on perinatal outcome. Endometriosis was established by the intraperitoneal injection of homologous minced mouse uteri. Vehicle was injected for the control.
View Article and Find Full Text PDFThe purpose of this study was to establish a novel mouse model of adenomyosis suitable for longitudinal and quantitative analyses and perinatal outcome studies. Using a 30 G needle, the entire uterine wall of one horn was mechanically punctured at a frequency of 100 times/1 cm (adenomyosis horn). The other horn was left unpunctured (control horn).
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