Publications by authors named "T Magnus"
Introduction: In Parkinson's disease (PD), axial symptom response to deep brain stimulation of the subthalamic nucleus (STN-DBS) is heterogeneous. This single-center, retrospective study aimed to assess imaging biomarkers of routine magnetic resonance imaging (MRI) to predict axial symptom response to STN-DBS, specifically by using an index of volumes of mesencephalon, pons, middle, and superior peduncle ("MR PIGD index").
Methods: We investigated 94 PD patients pre- and three to six months postoperatively by using MDS-UPDRS III, Berg Balance Scale, Freezing of Gait Questionnaire (FOG-Q) and Ziegler Course, which were related to regional brain volumetry information using regression analysis and partial least squares correlation analysis.
Article Synopsis
- The study aimed to assess the safety and effectiveness of caprylate/chromatography-purified intravenous immunoglobulin (IGIV-C) in patients with generalized myasthenia gravis (MG) compared to a placebo.
- A total of 62 patients participated in a randomized trial, where IGIV-C showed a numerical improvement in certain outcomes like activities of daily living, although most primary and secondary outcomes did not reach statistical significance.
- While IGIV-C was generally well-tolerated, the small size of the study suggests the need for further research to better understand its potential as a maintenance therapy for MG.
Background: The discrepancy between experimental research and clinical trial outcomes is a persistent challenge in preclinical studies, particularly in stroke research. A possible factor contributing to this issue is the lack of standardization across experimental stroke models, leading to poor reproducibility in multicenter studies. This study addresses this gap by aiming to enhance reproducibility and the efficacy of multicenter studies through the harmonization of protocols and training of involved personnel.
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- Supracondylar humerus fractures (SCHFs) are common elbow fractures in kids, often leading to complications like median nerve and anterior interosseus nerve (AIN) injuries.
- Ten children were studied over approximately 11.6 months, with evaluations including standardized exams, high-resolution ultrasounds, and electrodiagnostic studies to assess nerve injuries.
- The findings revealed that most children had median nerve injuries, showing good recovery with conservative treatment, despite initial severe nerve issues and the development of neuromas at the fracture site.