Publications by authors named "T Madden"
Background: Yttrium-90 FF-21101 (Y-FF-21101) is a radiopharmaceutical that targets P-cadherin as a therapy against solid tumors. A previously reported, first-in-human study determined that a dose of 25 mCi/m was safe, and a patient with clear cell carcinoma of the ovary achieved a complete response. In this article, the authors report the results of Y-FF-21101 treatment in an ovarian carcinoma expansion cohort and in patients with selected solid tumors who had known high P-cadherin expression.
View Article and Find Full Text PDFObjective: To evaluate implementation of a patient decision aid for symptomatic uterine fibroid management to improve shared decision-making at five clinical settings across the United States.
Methods: We used a type 3 hybrid effectiveness-implementation stepped-wedge design and the Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) planning and evaluation framework. We conducted clinician training, monthly reach tracking with feedback to site clinical leads, patient and clinician surveys, and visit audio-recordings.
T-CLEARE: a pilot community-driven tissue clearing protocol repository.
Front Bioeng Biotechnol
September 2024
Article Synopsis
- Tissue clearing is a science method that has been around for over 100 years, but it’s still changing and improving.
- Choosing the right tissue clearing method can be hard because there are many different protocols, each with pros and cons depending on the situation.
- To help scientists, a new online resource called T-CLEARE (Tissue CLEAring protocol REpository) has been created to share details and experiences about various tissue clearing methods and their results.
Article Synopsis
- Fibroids are non-cancerous growths in the uterus that can negatively affect quality of life, prompting the need for personalized treatment options and better communication tools for shared decision-making among patients and healthcare providers.* -
- A user-centered approach was used to develop two conversation aids—one text-based and one picture-enhanced—through stakeholder focus groups and user-testing interviews, with efforts made to translate them into Spanish simultaneously.* -
- Initial feedback from focus groups and user-testing showed the conversation aids were well-received, but ongoing implementation revealed the need for significant updates to reflect new treatment information and accommodate stakeholder suggestions.*
Aims: Researchers were invited by Aboriginal leaders to collaborate on this study which aimed to assess food intake in the Walgett Aboriginal community to inform long-term community-led efforts to improve food and water security and nutrition.
Methods: Aboriginal adults living in or near Walgett, a remote community in north-west NSW, Australia, completed an adapted Menzies Remote Short-item Dietary Assessment Tool, which was administered verbally and face-to-face in early 2022. Aboriginal people were involved in the survey design, training and collection, and analysis of data.